Kopras Elizabeth, Potluri Veena, Bermudez Mei-Ling, Williams Karin, Belcher Scott, Kasper Susan
Department of Environmental Heath, University of Cincinnati, 3223 Eden Avenue, Cincinnati, Ohio 45267-0056, USA Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267-0575, USA.
Endocr Relat Cancer. 2014 Mar 12;21(2):T1-12. doi: 10.1530/ERC-13-0360. Print 2014 Apr.
Development and fate of the stem cell are regulated by extrinsic signals from the environment. Endocrine-disrupting chemicals which perturb hormonal signaling in utero and during early childhood may cause deregulation of multiple developmental processes, ranging from breakdown of stem cell niche architecture, developmental reprograming and altered stem cell fate to impaired organ and gonad development and sexual differentiation. Therefore, study of the environmental effects on stem cell integrity and normal development is a new and emerging focus for developmental biologists and cell toxicologists. When combined with new human and mouse stem cell-based models, stem cell differentiation dynamics can be studied in more biologically relevant ways. In this study, we review the current status of our understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis.
干细胞的发育和命运受来自环境的外在信号调控。干扰子宫内和儿童早期激素信号的内分泌干扰化学物质可能导致多个发育过程失调，范围从干细胞生态位结构破坏、发育重编程、干细胞命运改变到器官和性腺发育受损以及性分化异常。因此，研究环境对干细胞完整性和正常发育的影响是发育生物学家和细胞毒理学家新出现的一个焦点。当与新的基于人和小鼠干细胞的模型相结合时，就可以用更具生物学相关性的方式研究干细胞分化动力学。在本研究中，我们综述了目前我们对内分泌干扰物改变胚胎干细胞和成人干细胞/祖细胞命运、器官发育、癌症干细胞活性及肿瘤发生的分子机制的理解现状。
