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关于肿瘤预防的新策略。

On a new strategy of preventive oncology.

机构信息

Russian-Armenian Scientific Medical Center, Yerevan, Armenia.

出版信息

Neurochem Res. 2010 Jun;35(6):868-74. doi: 10.1007/s11064-009-0110-x. Epub 2010 Jan 30.

Abstract

The etiology of cancer is much wider than separately taken causal agent and rests against the most complicated interrelation and mutuality of many external and internal influences. Our researches with use of fluorescing antibodies to AFP, CEA and Ca-19-9 have shown that they are intensively besieged on a surface of cultivated malignant cells. It is the basic mechanism of tolerance and immunological escape, which is similar to pregnancy when "the maximal immunological most favored status" to developing fetus (semiallogenic transplant) is provided. The earliest revealing of first cancer cells, before steady community of cells and tumor angiogenesis were formed, has particular importance in the fight against cancer. The necessity of the specific completion of the weakened antineoplastic resistibility of people from high oncological risk groups is substantiated. The activity in this direction brought forth the design of embryonic anti-tumor modulator (EATM). EATM is composed of a wide pool of fetal proteins and proteoglycans isolated exceptionally from normal embryonic substances.

摘要

癌症的病因比单独的致病因素要广泛得多,它与许多外部和内部影响的最复杂的相互关系和相互作用有关。我们使用荧光抗体 AFP、CEA 和 Ca-19-9 的研究表明,它们强烈地包围在培养的恶性细胞表面。这是一种耐受和免疫逃避的基本机制,类似于为发育中的胎儿(半同种移植)提供“最大免疫最有利状态”的妊娠。在细胞群稳定和肿瘤血管生成形成之前,最早揭示第一个癌细胞具有特别重要的抗癌意义。从高肿瘤风险人群中特异性完成减弱的抗肿瘤抵抗力的必要性得到了证实。这方面的活动产生了胚胎抗肿瘤调节剂(EATM)的设计。EATM 由一组广泛的胎儿蛋白和糖蛋白组成,这些蛋白和糖蛋白是从正常胚胎物质中异常分离出来的。

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