从美丽香科科中分离出的毛蕊花糖苷在体外对单纯疱疹病毒1型和单纯疱疹病毒2型具有抑制活性。
Verbascoside isolated from Lepechinia speciosa has inhibitory activity against HSV-1 and HSV-2 in vitro.
作者信息
Martins Fernanda O, Esteves Patricia F, Mendes Gabriella S, Barbi Nanci S, Menezes Fabio S, Romanos Maria T V
机构信息
Laboratório Experimental de Drogas Antivirais e Citotóxicas (LEDAC), Departamento de Virologia do Instituto de Microbiologia Prof Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Rio de Janeiro, Brasil.
出版信息
Nat Prod Commun. 2009 Dec;4(12):1693-6.
Verbascoside has been isolated form L. speciosa after several different chromatographic methods. After its purification, the structure has been unequivocally established using modern spectroscopic techniques. As for the antiviral activity, the maximum non toxic concentration has been established and this concentration has been used in the anti herpes assay, in vitro. Mechanism of action for this molecule regarding the anti-herpes activity has been studied encompassing the following assays: virucidal activity, cellular receptor assay, penetration assay and intracellular assay, in order to understand the activity for this natural product.
经过几种不同的色谱方法，从美丽喇叭花中分离出了毛蕊花糖苷。纯化后，利用现代光谱技术明确确定了其结构。至于抗病毒活性，已确定了最大无毒浓度，并将该浓度用于体外抗疱疹试验。针对该分子的抗疱疹活性作用机制进行了研究，包括以下试验：杀病毒活性试验、细胞受体试验、渗透试验和细胞内试验，以了解这种天然产物的活性。
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