两种具有抗分枝杆菌活性的马缨丹属植物的精油。
Essential oils from two Lantana species with antimycobacterial activity.
作者信息
Julião Lisieux de Santana, Bizzo Humberto R, Souza Andressa M, Lourenço Maria Cristina S, Silva Pedro Eduardo A, Tavares Eliana S, Rastrelli Luca, Leitão Suzana Guimarães
机构信息
Programa de Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, CCS, Bl. K. 2 andar, Rio de Janeiro, RJ, Brazil.
出版信息
Nat Prod Commun. 2009 Dec;4(12):1733-6.
Lantana trifolia L. and L. fucata Lindl. are two Brazilian species used in folk medicine for the treatment of respiratory disorders. The composition of the essential oils from the leaves was investigated, as well as their in vitro activity against Mycobacterium tuberculosis. L. trifolia yielded an oil (0.2%) rich in sesquiterpenes. The major substances found were germacrene D (45.1%), (E)-caryophyllene (12.8%), bicyclogermacrene (12.7%) and alpha-humulene (4.4%). Sesquiterpenes were also the main components of the oil of L. fucata (0.3% yield), the principal ones being beta-elemene (27.1%), germacrene D (11.6%), (E)-caryophyllene (7.7%), valencene (5.7%) and germacrene A (4.6%). Both oils exhibited in vitro antimycobacterial activity by the MABA assay with MICs of 80 microg/mL for L. trifolia and 100 microg/mL for L. fucata.
三裂叶马缨丹和褐毛马缨丹是巴西的两个物种，在民间医学中用于治疗呼吸系统疾病。对其叶片精油的成分进行了研究，并研究了它们对结核分枝杆菌的体外活性。三裂叶马缨丹产生一种富含倍半萜的油（0.2%）。发现的主要物质是杜松烯D（45.1%）、（E）-石竹烯（12.8%）、双环杜松烯（12.7%）和α-葎草烯（4.4%）。倍半萜也是褐毛马缨丹油（产率0.3%）的主要成分，主要成分是β-榄香烯（27.1%）、杜松烯D（11.6%）、（E）-石竹烯（7.7%）、瓦伦烯（5.7%）和杜松烯A（4.6%）。通过MABA试验，两种油均表现出体外抗分枝杆菌活性，三裂叶马缨丹的MIC为80微克/毫升，褐毛马缨丹的MIC为100微克/毫升。
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