Bućan Kajo, Ivanisević Milan, Zemunik Tatijana, Boraska Vesna, Skrabić Veselin, Vatavuk Zoran, Galetović Davor, Znaor Ljubo
Eye Clinic, Clinical Hospital Center Split, Split, Croatia.
Coll Antropol. 2009 Dec;33 Suppl 2:99-105.
Retinopathy and nephropathy are common late type 1 diabetes mellitus (T1D) complications. In this study we investigated whether individual differences in 4 candidate genes significantly contribute to development and progression of late complications in T1D patients. We examined 121 patients for the presence of diabetic retinopathy and nephropathy. We genotyped variants in vitamin D receptor (VDR) and tumor necrosis factor (TNF) genes in 47 patients and in NeuroD1 and interleukin-1 receptor 1 (IL1R1) genes in 35 patients. Diabetic retinopathy had 66 (55%) patients after a median of 13.0 years after diagnosis. Diabetic nephropathy had 14 (11.66%) patients, all of whom had already developed retinopathy. A significant correlation between the degree of diabetic retinopathy and mean microalbuminuria (MA) value has been found (chi2 = 54.18, p < 0.001). After correcting for duration of disease, only the VDR gene BsmI genotypes showed significant association with cumulative prevalence of diabetic retinopathy, while no investigated genetic polymorphysms could reliably predict diabetic nephropathy.
视网膜病变和肾病是常见的1型糖尿病（T1D）晚期并发症。在本研究中，我们调查了4个候选基因的个体差异是否对T1D患者晚期并发症的发生和发展有显著影响。我们检查了121例患者是否患有糖尿病视网膜病变和肾病。我们对47例患者的维生素D受体（VDR）和肿瘤坏死因子（TNF）基因变体进行了基因分型，对35例患者的NeuroD1和白细胞介素-1受体1（IL1R1）基因进行了基因分型。诊断后中位时间13.0年，有66例（55%）患者发生糖尿病视网膜病变。有14例（11.66%）患者发生糖尿病肾病，所有这些患者均已出现视网膜病变。已发现糖尿病视网膜病变程度与平均微量白蛋白尿（MA）值之间存在显著相关性（χ2 = 54.18，p < 0.001）。校正病程后，仅VDR基因BsmI基因型与糖尿病视网膜病变的累积患病率显示出显著相关性，而所研究的基因多态性均无法可靠地预测糖尿病肾病。
