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维生素D受体基因多态性与糖尿病肾病的关联：一项系统评价和荟萃分析。

Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis.

作者信息

Yang Lina, Wu Lan, Fan Yi, Ma Jianfei

机构信息

Department of Geriatrics, the First Affiliated Hospital of China Medical University, 155th Nanjing North Street, Shenyang, Liaoning, 110001, People's Republic of China.

Department of Nephrology, the First Affiliated Hospital of China Medical University, 155th Nanjing North Street, Shenyang, Liaoning, 110001, People's Republic of China.

出版信息

BMC Med Genet. 2017 Aug 29;18(1):95. doi: 10.1186/s12881-017-0458-8.

DOI:10.1186/s12881-017-0458-8
PMID:28851298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5575903/
Abstract

BACKGROUND

A large amount of researches have demonstrated that vitamin D receptor (VDR) gene polymorphisms are associated with diabetic nephropathy (DN) risk in diabetes mellitus (DM) patients. Nevertheless, the results are inconclusive and inconsistent.

METHODS

We screened PubMed, Embase, Chinese National Knowledge Infrastructure and Chinese Wanfang databases for those relevant studies updated in May 2016.

RESULTS

7 studies involving 2564 subjects were recruited. We evaluated the genotypic and allelic differences between DN patients and DM controls. Overall analysis showed that no significant association was found among the ApaI, BsmI, FokI,TaqI gene polymorphisms and DN susceptibility in diabetic patients (all P values > 0.05). In the stratified analysis, TT genotype was related to DN susceptibility in Asians (TT vs Tt + tt: OR =2.21, 95% CI: 1.05-4.67, p = 0.04). The sensitivity analysis showed that the results in overall populations, Caucasians and Asians were dependable.

CONCLUSIONS

No significant association was found among the ApaI, BsmI, FokI, TaqI polymorphisms and DN risk in overall populations, the TaqI variants might related to DN susceptibility in Asians. Further researches are required to testify our meta-analysis.

摘要

背景

大量研究表明，维生素D受体（VDR）基因多态性与糖尿病（DM）患者的糖尿病肾病（DN）风险相关。然而，结果尚无定论且不一致。

方法

我们在PubMed、Embase、中国知网和中国万方数据库中筛选了2016年5月更新的相关研究。

结果

纳入了7项研究，共2564名受试者。我们评估了DN患者与DM对照之间的基因型和等位基因差异。总体分析表明，在糖尿病患者中，ApaI、BsmI、FokI、TaqI基因多态性与DN易感性之间未发现显著关联（所有P值>0.05）。在分层分析中，TT基因型与亚洲人的DN易感性相关（TT与Tt+tt比较：OR=2.21，95%CI：1.05-4.67，p=0.04）。敏感性分析表明，总体人群、白种人和亚洲人的结果可靠。

结论

在总体人群中，ApaI、BsmI、FokI、TaqI多态性与DN风险之间未发现显著关联，TaqI变异可能与亚洲人的DN易感性有关。需要进一步的研究来证实我们的荟萃分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/617d4a610dba/12881_2017_458_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/d485bc38e34b/12881_2017_458_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/0e2c480c114d/12881_2017_458_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/f88e8298e7a1/12881_2017_458_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/8c28ca4f9dda/12881_2017_458_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/617d4a610dba/12881_2017_458_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/d485bc38e34b/12881_2017_458_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/0e2c480c114d/12881_2017_458_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/f88e8298e7a1/12881_2017_458_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/8c28ca4f9dda/12881_2017_458_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9760/5575903/617d4a610dba/12881_2017_458_Fig5_HTML.jpg

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