Jiao JingHua, Li Yan, Xu Shuang, Wu Jingyang, Yue Song, Liu Lei
Department of Anesthesiology, Central Hospital, Shenyang Medical College, 110024 Shenyang, China.
Department of English, School of Fundamental Sciences, China Medical University, 110122 Shenyang, China.
Afr Health Sci. 2018 Dec;18(4):891-899. doi: 10.4314/ahs.v18i4.7.
To assess synthetically the association between polymorphisms in the vitamin D receptor (VDR) gene (FokI, BsmI, ApaI, and TaqI) and diabetic retinopathy (DR).
Pubmed, Embase, ISI Web of Science, Google-scholar and CBMDisc, CNKI and Chongqing VIP databases were searched. A meta-analysis was performed.
Six studies with 636 cases and 1,035 controls were included in this meta-analysis. The outcomes showed that the FokI polymorphism (F allele) of VDR gene had no statistical protective relationship with DR in overall studies. Interestingly, stratification analysis showed that the FokI polymorphism (Fallele) was significantly associated with decreased DR risk in the Chinese population, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. However, the TaqI, BsmI and ApaI polymorphisms of VDR gene had no significant association with the risk of DR.
This meta-analysis of case-control studies revealed that the VDR-FokI polymorphism (F allele) decreased the risk of DR in Chinese people, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. Further rigorous and prospective studies with large sample size are needed to confirm our findings.
综合评估维生素D受体（VDR）基因（FokI、BsmI、ApaI和TaqI）多态性与糖尿病视网膜病变（DR）之间的关联。
检索了PubMed、Embase、ISI Web of Science、Google学术和中国生物医学文献数据库、中国知网和重庆维普数据库。进行了荟萃分析。
本荟萃分析纳入了6项研究，共636例病例和1035例对照。结果显示，在总体研究中，VDR基因的FokI多态性（F等位基因）与DR无统计学上的保护关系。有趣的是，分层分析显示，在无发表偏倚的纳入研究中、正常受试者与DR患者的比较分析中以及2010年后发表的文章中，FokI多态性（F等位基因）与中国人群中DR风险降低显著相关。然而，VDR基因的TaqI、BsmI和ApaI多态性与DR风险无显著关联。
这项病例对照研究的荟萃分析表明，在无发表偏倚的纳入研究中、正常受试者与DR患者的比较分析中以及2010年后发表的文章中，VDR-FokI多态性（F等位基因）降低了中国人患DR的风险。需要进一步进行严格的大样本前瞻性研究来证实我们的发现。
