Center for Sleep Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Sleep. 2010 Jan;33(1):81-7.
To determine the frequency of impulse control disorders (ICDs) with the use of dopaminergic agents in restless legs syndrome (RLS).
Prospective case-control study using a screening questionnaire for ICDs, followed by phone interview to confirm diagnoses for those meeting preset scoring thresholds on the questionnaire.
Academic, comprehensive sleep medicine center.
(1) One hundred patients with RLS treated with dopaminergic agents, (2) 275 patients with obstructive sleep apnea (OSA) without RLS or exposure to dopaminergic agents; and (3) 52 patients with RLS who were never treated with dopaminergic agents. Subjects with parkinsonism were excluded.
Not applicable.
Based on the questionnaire, frequencies of ICDs for the RLS treatment group were 10% compulsive shopping, 7% pathologic gambling, 23% compulsive eating, 8% hypersexuality, and 10% punding. These values were statistically significant when compared with control subjects with OSA for compulsive shopping and pathologic gambling. With additional information from the phone interview, adjusted frequencies for the RLS treatment group were 9% compulsive shopping, 5% pathologic gambling, 11% compulsive eating, 3% hypersexuality, 7% punding, and 17% any ICD. These values were statistically significant when compared with those of control subjects with OSA for compulsive shopping, pathologic gambling, punding, and any ICD, as well as for compulsive shopping when compared with control subjects with RLS who were not treated with dopaminergic agents. In the RLS treatment group, a statistically significant dose effect was found for pramipexole in those subjects confirmed to have ICDs by both the questionnaire and phone interview. Mean duration of treatment at ICD onset was 9.5 months.
ICDs are common with the use of dopaminergic agents for treatment of RLS. Given the potentially devastating psychosocial consequences of these behaviors, it is critical to actively screen for ICDs in this population.
确定使用多巴胺能药物治疗不宁腿综合征（RLS）时冲动控制障碍（ICD）的频率。
使用 ICD 筛查问卷进行前瞻性病例对照研究，然后通过电话访谈确认那些在问卷中达到预设评分阈值的患者的诊断。
学术性综合睡眠医学中心。
（1）100 名接受多巴胺能药物治疗的 RLS 患者；（2）275 名无 RLS 或未接触多巴胺能药物的阻塞性睡眠呼吸暂停（OSA）患者；（3）52 名从未接受过多巴胺能药物治疗的 RLS 患者。排除帕金森病患者。
不适用。
根据问卷，RLS 治疗组 ICD 的频率分别为：10%强迫性购物、7%病理性赌博、23%强迫性进食、8%性欲亢进和 10%冲动性打砸行为。与 OSA 对照组相比，这些值在强迫性购物和病理性赌博方面具有统计学意义。通过电话访谈获得更多信息后，RLS 治疗组调整后的频率分别为：9%强迫性购物、5%病理性赌博、11%强迫性进食、3%性欲亢进、7%冲动性打砸行为和 17%任何 ICD。与 OSA 对照组相比，这些值在强迫性购物、病理性赌博、冲动性打砸行为和任何 ICD 方面均具有统计学意义，与未接受多巴胺能药物治疗的 RLS 对照组相比，仅在强迫性购物方面具有统计学意义。在 RLS 治疗组中，对于通过问卷和电话访谈均确诊为 ICD 的患者，发现普拉克索的剂量与 ICD 之间存在统计学显著的剂量效应。ICD 发病时的平均治疗时间为 9.5 个月。
使用多巴胺能药物治疗 RLS 时，ICD 很常见。鉴于这些行为可能产生严重的社会心理后果，因此在该人群中积极筛查 ICD 至关重要。
