Miao Ailin, Wan Meizhen, Cheng Lei
Department of Otorhinolaryngology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;23(19):881-3.
To investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-C (VEGF-C) in papillary thyroid carcinoma and their relationship to cervical lymph metastases.
In this study, the expressions of COX-2 and VEGF-C were examined by immunohistochemistry in papillary thyroid carcinoma tissues of 40 patients, and analysis was performed on the correlation of cervical lymph metastases with COX-2 and VEGF-C expression.
Positive expressions of COX-2 and VEGF-C were 70.0% (28/40) and 75.0% (30/40) respectively in papillary thyroid carcinoma. The positive rates of COX-2 and VEGF-C expression were 80.8% (21/26) and 84.6% (22/26) respectively in patients with cervical lymph metastases, and 50.0% (7/14) and 57.1% (8/14) respectively in patients without cervical lymph metastases, with a statistically significant difference between two groups (P<0.05, all). COX-2 was positively correlated to VEGF-C expression in papillary thyroid carcinoma (r=0.378, P<0.05).
The results suggest that COX-2 and VEGF-C were highly expressed in papillary thyroid carcinoma, with possible interaction of their expressions, and may play a critical role in the cervical lymph metastases of papillary thyroid carcinoma.
探讨环氧化酶-2（COX-2）和血管内皮生长因子-C（VEGF-C）在甲状腺乳头状癌中的表达及其与颈部淋巴结转移的关系。
本研究采用免疫组织化学法检测40例甲状腺乳头状癌组织中COX-2和VEGF-C的表达，并分析颈部淋巴结转移与COX-2和VEGF-C表达的相关性。
甲状腺乳头状癌中COX-2和VEGF-C的阳性表达率分别为70.0%（28/40）和75.0%（30/40）。颈部淋巴结转移患者中COX-2和VEGF-C的表达阳性率分别为80.8%（21/26）和84.6%（22/26），无颈部淋巴结转移患者中分别为50.0%（7/14）和57.1%（8/14），两组差异有统计学意义（P<0.05，均）。甲状腺乳头状癌中COX-2与VEGF-C表达呈正相关（r=0.378，P<0.05）。
结果表明，COX-2和VEGF-C在甲状腺乳头状癌中高表达，其表达可能存在相互作用，且可能在甲状腺乳头状癌颈部淋巴结转移中起关键作用。
