Flokstra-de Blok B M J, van der Meulen G N, DunnGalvin A, Vlieg-Boerstra B J, Oude Elberink J N G, Duiverman E J, Hourihane J O'B, Dubois A E J
Department of Paediatrics, Division of Paediatric Pulmonology and Paediatric Allergy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Allergy. 2009 Aug;64(8):1209-17. doi: 10.1111/j.1398-9995.2009.01968.x. Epub 2009 Feb 11.
Health-related quality of life (HRQL) may be affected by food allergy. Presently, no disease-specific HRQL questionnaire exists for food allergic adults. Therefore, we developed and validated the Food Allergy Quality of Life Questionnaire - Adult Form (FAQLQ-AF) in the Dutch language.
Twenty-two food allergic patients (> or =18 years) were interviewed and generated 180 HRQL items. The most important items were identified by 54 food allergic patients using the clinical impact method resulting in the FAQLQ-AF containing 29 items (score range 1 'not troubled' to 7 'extremely troubled'). The FAQLQ-AF, the Food Allergy Independent Measure (FAIM) and a generic HRQL questionnaire (RAND-36) were sent to 100 other food allergic adults for cross-sectional validation of the FAQLQ-AF.
Cross-sectional validity was assessed by the correlation between FAQLQ-AF and FAIM (rho = 0.76, P < 0.001). The FAQLQ-AF had excellent internal consistency (Cronbach's alpha = 0.97). The FAQLQ-AF discriminated between patients who differ in severity of symptoms (anaphylaxis vs no anaphylaxis, total FAQLQ-AF score 4.9 vs 4.1; P = 0.041) and number of food allergies (>3 food allergies vs< or =3 food allergies, total FAQLQ-AF score 5.2 vs 4.2; P = 0.008). The total FAQLQ-AF score was correlated with one RAND-36 scale (convergent/discriminant validity).
The FAQLQ-AF is the first disease-specific HRQL questionnaire for food allergic adults and reflects the most important issues that food allergic patients have to face. The questionnaire is valid, reliable and discriminates between patients with different disease characteristics. The FAQLQ-AF is short and easy to use and may therefore be a useful tool in clinical research.
与健康相关的生活质量（HRQL）可能会受到食物过敏的影响。目前，尚无专门针对食物过敏成人的特定疾病HRQL问卷。因此，我们开发并验证了荷兰语版的《食物过敏生活质量问卷 - 成人版》（FAQLQ - AF）。
对22名食物过敏患者（≥18岁）进行访谈，收集了180个HRQL项目。54名食物过敏患者使用临床影响法确定了最重要的项目，由此产生了包含29个项目的FAQLQ - AF（评分范围为1“无困扰”至7“极度困扰”）。将FAQLQ - AF、食物过敏独立测量法（FAIM）和一份通用HRQL问卷（RAND - 36）发送给另外100名食物过敏成人，以对FAQLQ - AF进行横断面验证。
通过FAQLQ - AF与FAIM之间的相关性评估横断面效度（rho = 0.76，P < 0.001）。FAQLQ - AF具有出色的内部一致性（Cronbach's alpha = 0.97）。FAQLQ - AF能够区分症状严重程度不同的患者（过敏反应患者与无过敏反应患者，FAQLQ - AF总分4.9对4.1；P = 0.041）以及食物过敏数量不同的患者（>3种食物过敏患者与≤3种食物过敏患者，FAQLQ - AF总分5.2对4.2；P = 0.008）。FAQLQ - AF总分与一个RAND - 36量表相关（收敛/区分效度）。
FAQLQ - AF是首个针对食物过敏成人的特定疾病HRQL问卷，反映了食物过敏患者必须面对的最重要问题。该问卷有效、可靠，能够区分具有不同疾病特征的患者。FAQLQ - AF简短且易于使用，因此可能是临床研究中的一个有用工具。
