Flokstra-de Blok B M J, DunnGalvin A, Vlieg-Boerstra B J, Oude Elberink J N G, Duiverman E J, Hourihane J O'B, Dubois A E J
Department of Paediatrics, Division of Paediatric Pulmonology and Paediatric Allergy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Clin Exp Allergy. 2009 Jan;39(1):127-37. doi: 10.1111/j.1365-2222.2008.03120.x. Epub 2008 Oct 30.
Having a food allergy may affect health-related quality of life (HRQL). Currently, no validated, self-administered, disease-specific HRQL questionnaire exists for children with food allergy.
The aim of this study was to develop and validate the Food Allergy Quality of Life Questionnaire--Child Form (FAQLQ-CF) in the Dutch language.
Interviews with food-allergic children (n=13, 8-12 years) generated 139 HRQL items. The most important items were identified by 51 food-allergic children using the clinical impact method. This resulted in the FAQLQ-CF containing 24 items (total score range 1 'not troubled' to 7 'extremely troubled'). The FAQLQ-CF, the Food Allergy Independent Measure (FAIM) and a generic HRQL questionnaire (CHQ-CF87) were sent to 115 food-allergic children for cross-sectional validation of the FAQLQ-CF.
Construct validity was demonstrated by the correlation between the FAQLQ-CF and the FAIM (rho=0.60, P<0.001). The FAQLQ-CF had an excellent internal consistency (Cronbach's alpha=0.94) and discriminated between children who differed in number of food allergies (>2 food allergies vs. < or =2 food allergies; total FAQLQ-CF score, 4.3 vs. 3.6; P=0.036), but did not discriminate between reported anaphylaxis or not. The total FAQLQ-CF score correlated with 8 of the 11 CHQ-CF87 sub-scales which demonstrated convergent/discriminant validity.
The FAQLQ-CF is the first self-administered disease-specific HRQL questionnaire for food-allergic children. This questionnaire has a strong internal consistency and cross-sectional validity. It discriminates between children who differ in number of food allergies, and it was short and easy to use in the population studied. Therefore, the FAQLQ-CF may be a useful tool in clinical research.
患有食物过敏可能会影响与健康相关的生活质量（HRQL）。目前，尚无经过验证的、可自行填写的针对食物过敏儿童的特定疾病HRQL问卷。
本研究旨在开发并验证荷兰语版的食物过敏生活质量问卷——儿童版（FAQLQ-CF）。
对13名8至12岁的食物过敏儿童进行访谈，共产生139个HRQL项目。51名食物过敏儿童采用临床影响法确定了最重要的项目。由此产生的FAQLQ-CF包含24个项目（总分范围为1“无困扰”至7“极度困扰”）。将FAQLQ-CF、食物过敏独立测量量表（FAIM）和一份通用HRQL问卷（CHQ-CF87）发送给115名食物过敏儿童，以对FAQLQ-CF进行横断面验证。
FAQLQ-CF与FAIM之间的相关性证明了结构效度（rho=0.60，P<0.001）。FAQLQ-CF具有出色的内部一致性（Cronbach's alpha=0.94），并且能够区分食物过敏数量不同的儿童（>2种食物过敏与≤2种食物过敏；FAQLQ-CF总分，4.3对3.6；P=0.036），但无法区分是否发生过过敏反应。FAQLQ-CF总分与CHQ-CF87的11个分量表中的8个相关，证明了其收敛/区分效度。
FAQLQ-CF是首个供食物过敏儿童自行填写的特定疾病HRQL问卷。该问卷具有很强的内部一致性和横断面效度。它能够区分食物过敏数量不同的儿童，并且简短易用，适用于所研究的人群。因此，FAQLQ-CF可能是临床研究中的一个有用工具。
