Department of Neurology, School of Medicine, Boston University, Boston, MA 02130, USA.
J Am Geriatr Soc. 2009 Dec;57(12):2300-5. doi: 10.1111/j.1532-5415.2009.02559.x.
To evaluate effects of health status on word-finding difficulty in aging, adjusting for the known contributors of education, sex, and ethnicity.
Cross-sectional.
Community.
Two hundred eighty-four adults aged 55 to 85 (48.6% female) participating in an ongoing longitudinal study of language in aging.
Medical, neurological, and laboratory evaluations to determine health status and presence or absence of hypertension and diabetes mellitus. Lexical retrieval evaluated with the Boston Naming Test (BNT) and Action Naming Test.
Unadjusted regression models showed that presence of diabetes mellitus was not related to naming. Presence of hypertension was associated with significantly lower accuracy on both tasks (P<.02). Adjustment for demographics attenuated the effect of hypertension (P<.08). For the BNT, a variable combining presence, treatment, and control of hypertension was marginally significant (P<.10), with subjects with uncontrolled hypertension being least accurate (91.4%). Previously observed findings regarding the effects of age, education, sex, and ethnicity were confirmed.
In this sample of older adults, hypertension contributed to the word-finding difficulty of normal aging, but diabetes mellitus did not.
评估健康状况对衰老过程中单词查找困难的影响，同时调整已知的教育、性别和种族因素的影响。
横断面研究。
社区。
284 名年龄在 55 至 85 岁之间的成年人（48.6%为女性），他们参与了一项正在进行的关于衰老过程中语言的纵向研究。
进行医学、神经学和实验室评估，以确定健康状况以及是否存在高血压和糖尿病。使用波士顿命名测试（BNT）和动作命名测试评估词汇检索。
未调整的回归模型显示，糖尿病的存在与命名无关。高血压的存在与两项任务的准确性显著降低相关（P<.02）。调整人口统计学因素后，高血压的影响减弱（P<.08）。对于 BNT，一个结合了高血压的存在、治疗和控制的变量具有边缘显著意义（P<.10），未控制的高血压患者的准确性最低（91.4%）。先前观察到的与年龄、教育、性别和种族有关的影响得到了证实。
在这个老年人群样本中，高血压导致了正常衰老过程中的单词查找困难，但糖尿病没有。
