SLE 中神秘的 CD4+CD25-Foxp3+细胞的鉴定。
Identity of mysterious CD4+CD25-Foxp3+ cells in SLE.
出版信息
Arthritis Res Ther. 2010;12(1):101. doi: 10.1186/ar2894. Epub 2010 Jan 20.
Abstract
Various abnormalities in CD4+CD25+ regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) include increased Foxp3+ cells that are CD25 negative. Barring methodological technical factors, these cells could be atypical Tregs or activated non-Treg CD4+ cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3+ non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3+CD4+CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity.
摘要
系统性红斑狼疮（SLE）患者的 CD4+CD25+调节性 T 细胞（Tregs）存在多种异常，包括 Foxp3+细胞 CD25 阴性比例增加。排除方法学技术因素，这些细胞可能是不典型的 Tregs 或表达 Foxp3 的激活的非 Treg CD4+细胞。两组得出了相反的结论，这可能反映了研究对象的差异。一组研究了未经治疗的新发 SLE，提示这些 T 细胞主要是 CD25-Foxp3+非 Tregs。另一组研究了患有长期疾病的患者，提示这些细胞主要是功能失调的 Tregs。第三组报道在活动期 SLE 中 Foxp3+CD4+CD25dim 细胞而非 CD25-细胞增加，这些细胞也不是 Tregs。因此，SLE 中并非所有 Foxp3+T 细胞都具有保护性抑制活性。
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