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Identity of mysterious CD4+CD25-Foxp3+ cells in SLE.SLE 中神秘的 CD4+CD25-Foxp3+细胞的鉴定。
Arthritis Res Ther. 2010;12(1):101. doi: 10.1186/ar2894. Epub 2010 Jan 20.
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CD4CD69 T cells and CD4CD25FoxP3 Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice.从 pristane 诱导的系统性红斑狼疮 (SLE) 小鼠的外周血、脾脏和腹腔灌洗液中发现 CD4CD69 T 细胞和 CD4CD25FoxP3 Treg 细胞失衡。
Adv Rheumatol. 2019 Jul 24;59(1):30. doi: 10.1186/s42358-019-0072-x.
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Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus.系统性红斑狼疮中CD4(+) FoxP3(+)调节性T细胞亚群的稳态改变
Immunology. 2009 Jun;127(2):196-205. doi: 10.1111/j.1365-2567.2008.02937.x. Epub 2008 Sep 16.
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Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.系统性红斑狼疮患者 CD4(+) T 细胞对维 A 酸和 TGFβ 的反应缺陷。
Arthritis Res Ther. 2011 Jun 27;13(3):R106. doi: 10.1186/ar3387.
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Analysis of FOXP3 regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus.系统性红斑狼疮患者外周血和组织中FOXP3调节性T细胞亚群的分析
Immunol Res. 2017 Apr;65(2):551-563. doi: 10.1007/s12026-017-8904-4.
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Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus.新发系统性红斑狼疮患者中CD4+CD25-Foxp3+ T细胞增加的临床意义
Ann Rheum Dis. 2008 Jul;67(7):1037-40. doi: 10.1136/ard.2007.083543. Epub 2008 Jan 16.
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[Analysis of Foxp3+ CD4+ CD25+ regulatory cells in peripheral blood of patients with SLE].[系统性红斑狼疮患者外周血中Foxp3 + CD4 + CD25 +调节性细胞的分析]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 May;23(5):432-5.
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CD4(+)CD25(+)CD127(-) and CD4(+)CD25(+)Foxp3(+) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients.CD4(+)CD25(+)CD127(-)和CD4(+)CD25(+)Foxp3(+)调节性T细胞亚群在系统性红斑狼疮患者自身免疫反应中的作用
Arch Immunol Ther Exp (Warsz). 2016 Oct;64(5):399-407. doi: 10.1007/s00005-016-0399-5. Epub 2016 May 7.
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Low expressions of PD-L1 and CTLA-4 by induced CD4CD25 Foxp3 Tregs in patients with SLE and their correlation with the disease activity.SLE 患者诱导的 CD4CD25 Foxp3 Treg 细胞中 PD-L1 和 CTLA-4 的低表达及其与疾病活动的相关性。
Cytokine. 2020 Sep;133:155119. doi: 10.1016/j.cyto.2020.155119. Epub 2020 Jun 11.
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Increased CD4CD25Foxp3 T cells in Chinese systemic lupus erythematosus: correlate with disease activity and organ involvement.中国系统性红斑狼疮患者中CD4CD25Foxp3 T细胞增加：与疾病活动度及器官受累相关
Lupus. 2018 Nov;27(13):2057-2068. doi: 10.1177/0961203318804881. Epub 2018 Oct 18.
引用本文的文献
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Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways.通过抑制真核生物翻译起始因子5A（eIF5A）和Notch信号通路将1型糖尿病/成人隐匿性自身免疫性糖尿病中的效应T细胞转化为调节性T细胞
Immunotargets Ther. 2025 Mar 13;14:205-226. doi: 10.2147/ITT.S504555. eCollection 2025.
2
Single-Cell RNA Sequencing Reveals Unique Alterations in the Immune Panorama and Treg Subpopulations in Mice during the Late Stages of Echinococcus granulosus Infection.单细胞 RNA 测序揭示了在细粒棘球蚴感染后期阶段小鼠免疫全景和 Treg 亚群中的独特改变。
Infect Immun. 2023 May 16;91(5):e0002923. doi: 10.1128/iai.00029-23. Epub 2023 Apr 11.
3
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections.自身免疫性疾病的先天和适应性免疫异常：遗传关联。
Sci China Life Sci. 2023 Jul;66(7):1482-1517. doi: 10.1007/s11427-021-2187-3. Epub 2023 Feb 3.
4
The proportion and phenotypic changes of CD4CD25Foxp3 T cells in patients with untreated rheumatoid arthritis.未经治疗的类风湿关节炎患者中 CD4CD25Foxp3 T 细胞的比例和表型变化。
BMC Immunol. 2022 Sep 6;23(1):41. doi: 10.1186/s12865-022-00517-0.
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Genetic Variations Controlling Regulatory T Cell Development and Activity in Mouse Models of Lupus-Like Autoimmunity.控制狼疮样自身免疫小鼠模型中调节性 T 细胞发育和活性的遗传变异。
Front Immunol. 2022 May 26;13:887489. doi: 10.3389/fimmu.2022.887489. eCollection 2022.
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Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity.人类自身免疫性疾病、移植及肿瘤免疫中调节性T细胞的不同亚群。
MedComm (2020). 2022 Apr 21;3(2):e137. doi: 10.1002/mco2.137. eCollection 2022 Jun.
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Lupus nephritis with corticosteroid responsiveness: molecular changes of CD46-mediated type 1 regulatory T cells.狼疮性肾炎伴糖皮质激素反应性：CD46 介导的 1 型调节性 T 细胞的分子变化。
Pediatr Res. 2022 Oct;92(4):1099-1107. doi: 10.1038/s41390-021-01882-z. Epub 2021 Dec 24.
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CD4 T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease.CD4 T 细胞在非传染性视网膜炎症性疾病中的可塑性。
Int J Mol Sci. 2021 Sep 3;22(17):9584. doi: 10.3390/ijms22179584.
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Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.狼疮易感性基因 Esrrg 通过线粒体代谢调节调节性 T 细胞。
JCI Insight. 2021 Jul 22;6(14):e143540. doi: 10.1172/jci.insight.143540.
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Highly Multiplexed Mass Cytometry Identifies the Immunophenotype in the Skin of Dermatomyositis.高多重化质谱细胞术鉴定皮肌炎皮肤中的免疫表型。
J Invest Dermatol. 2021 Sep;141(9):2151-2160. doi: 10.1016/j.jid.2021.02.748. Epub 2021 Mar 22.
本文引用的文献
1
Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?未经治疗的新发狼疮患者中的 CD4+CD25-Foxp3+细胞是否为调节性 T 细胞？
Arthritis Res Ther. 2009;11(5):R153. doi: 10.1186/ar2829. Epub 2009 Oct 12.
2
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.表达FoxP3转录因子的人CD4+ T细胞的功能划分与分化动力学
Immunity. 2009 Jun 19;30(6):899-911. doi: 10.1016/j.immuni.2009.03.019. Epub 2009 May 21.
3
Regulatory T cells in the control of host-microorganism interactions (*).调节性T细胞在宿主-微生物相互作用的调控中（*）。
Annu Rev Immunol. 2009;27:551-89. doi: 10.1146/annurev.immunol.021908.132723.
4
Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus.系统性红斑狼疮患者中CD4+ CD25- Foxp3+ T细胞的表型和功能分析
J Immunol. 2009 Feb 1;182(3):1689-95. doi: 10.4049/jimmunol.182.3.1689.
5
Regulatory T cells in systemic lupus erythematosus: past, present and future.系统性红斑狼疮中的调节性T细胞：过去、现在与未来
Arthritis Res Ther. 2008;10(6):227. doi: 10.1186/ar2511. Epub 2008 Nov 14.
6
Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells.人工抗原呈递细胞上表达的肿瘤坏死因子受体家族成员OX40和4-1BB对脐带血调节性T细胞扩增及功能的影响
Blood. 2008 Oct 1;112(7):2847-57. doi: 10.1182/blood-2008-01-132951. Epub 2008 Jul 21.
7
Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus.新发系统性红斑狼疮患者中CD4+CD25-Foxp3+ T细胞增加的临床意义
Ann Rheum Dis. 2008 Jul;67(7):1037-40. doi: 10.1136/ard.2007.083543. Epub 2008 Jan 16.
8
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.抗TNF-α疗法通过转化生长因子-β在类风湿关节炎患者中诱导出独特的调节性T细胞群体。
J Exp Med. 2007 Jan 22;204(1):33-9. doi: 10.1084/jem.20061531. Epub 2007 Jan 2.
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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.CD127的表达与人类CD4+调节性T细胞的FoxP3及抑制功能呈负相关。
J Exp Med. 2006 Jul 10;203(7):1701-11. doi: 10.1084/jem.20060772. Epub 2006 Jul 3.
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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.正常和FOXP3突变型人类T细胞的单细胞分析：无调节性T细胞发育的FOXP3表达
Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64. doi: 10.1073/pnas.0509484103. Epub 2006 Apr 14.
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