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人类基因组与运动,包括表观遗传学、基因兴奋剂和运动基因组学。

The human genome and sport, including epigenetics, gene doping, and athleticogenomics.

机构信息

Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, West London, UK.

出版信息

Endocrinol Metab Clin North Am. 2010 Mar;39(1):201-15, xi. doi: 10.1016/j.ecl.2009.10.010.

Abstract

Hugh Montgomery's discovery of the first of more than 239 fitness genes together with rapid advances in human gene therapy have created a prospect of using genes, genetic elements, and cells that have the capacity to enhance athletic performance (to paraphrase the World Anti-Doping Agency's definition of gene doping). This brief overview covers the main areas of interface between genetics and sport, attempts to provide a context against which gene doping may be viewed, and predicts a futuristic legitimate use of genomic (and possibly epigenetic) information in sport.

摘要

休·蒙哥马利发现了 239 多个以上的适应能力基因中的第一个,再加上人类基因治疗的迅速进步,为利用具有提高运动表现能力的基因、遗传因子和细胞创造了前景(用世界反兴奋剂机构对基因兴奋剂的定义来转述)。本简要综述涵盖了遗传学与运动之间的主要接口领域,试图提供一个可以观察基因兴奋剂的背景,并预测基因组(可能还有表观遗传)信息在运动中的未来合法用途。

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