Eberhard M L, Dickerson J W, Boyer A E, Tsang V C, Zea-Flores R, Walker E M, Richards F O, Zea-Flores G, Strobert E
Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia.
Am J Trop Med Hyg. 1991 Feb;44(2):151-60. doi: 10.4269/ajtmh.1991.44.151.
Three chimpanzees, three mangabey monkeys (Cercocebus atys), and 14 patas monkeys (Erythrocebus patas) were inoculated with L3 Onchocerca volvulus of Guatemalan origin. One chimpanzee and two mangabey monkeys developed antibody activity to at least three different antigens. Both mangabey monkeys recognized a 20 kDa antigen 3.5-5 months post-inoculation, and the monkeys and the chimpanzee developed antibody activity to 14 and 22 kDa antigens 7.5-13 months post-inoculation. One mangabey monkey and the chimpanzee became microfilaria-positive in skin snips at 16 and 21 months post-inoculation, respectively. Antibody activity to the 20 kDa antigen in the mangabey monkeys is noteworthy because of the prominence of this antigen among putatively immune persons living in onchocerciasis-endemic areas. The two mangabey monkeys responded parasitologically in a manner comparable to immune humans. No microfilariae were detected in one monkey and only scant numbers of microfilariae were observed in the second. The mangabey monkey may be a good animal model for the study of onchocerciasis.
三只黑猩猩、三只白眉猴（白眉猴属阿蒂白眉猴）和十四只赤猴（赤猴）接种了源自危地马拉的旋盘尾丝虫L3期幼虫。一只黑猩猩和两只白眉猴产生了针对至少三种不同抗原的抗体活性。两只白眉猴在接种后3.5至5个月识别出一种20 kDa的抗原，这些猴子和黑猩猩在接种后7.5至13个月产生了针对14 kDa和22 kDa抗原的抗体活性。一只白眉猴和黑猩猩分别在接种后16个月和21个月时皮肤切片中微丝蚴呈阳性。白眉猴中针对20 kDa抗原的抗体活性值得关注，因为该抗原在盘尾丝虫病流行地区的假定免疫人群中较为突出。这两只白眉猴在寄生虫学方面的反应与免疫的人类相似。在一只猴子中未检测到微丝蚴，在另一只猴子中仅观察到少量微丝蚴。白眉猴可能是研究盘尾丝虫病的良好动物模型。
