在啮齿动物股神经模型中，运动感觉方式的匹配对周围神经再生没有增强作用。
Matching of motor-sensory modality in the rodent femoral nerve model shows no enhanced effect on peripheral nerve regeneration.
机构信息
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110-1010, USA.
出版信息
Exp Neurol. 2010 Jun;223(2):496-504. doi: 10.1016/j.expneurol.2010.01.016. Epub 2010 Feb 1.
Abstract
The treatment of peripheral nerve injuries with nerve gaps largely consists of autologous nerve grafting utilizing sensory nerve donors. Underlying this clinical practice is the assumption that sensory autografts provide a suitable substrate for motoneuron regeneration, thereby facilitating motor endplate reinnervation and functional recovery. This study examined the role of nerve graft modality on axonal regeneration, comparing motor nerve regeneration through motor, sensory, and mixed nerve isografts in the Lewis rat. A total of 100 rats underwent grafting of the motor or sensory branch of the femoral nerve with histomorphometric analysis performed after 5, 6, or 7 weeks. Analysis demonstrated similar nerve regeneration in motor, sensory, and mixed nerve grafts at all three time points. These data indicate that matching of motor-sensory modality in the rat femoral nerve does not confer improved axonal regeneration through nerve isografts.
摘要
用自体神经移植物修复有神经间隙的周围神经损伤主要是利用感觉神经供体。这种临床实践的基础是假设感觉自体移植物为运动神经元再生提供了合适的基质，从而促进运动终板再支配和功能恢复。本研究通过比较 Lewis 大鼠运动神经通过运动、感觉和混合神经同种异体移植物的再生，探讨了神经移植物方式对轴突再生的作用。共 100 只大鼠进行了股神经运动支或感觉支的移植，分别在术后 5、6 和 7 周进行组织形态计量学分析。分析表明，在所有三个时间点，运动神经、感觉神经和混合神经同种异体移植物的神经再生相似。这些数据表明，在大鼠股神经中匹配运动-感觉方式并不能通过神经同种异体移植物改善轴突再生。
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