Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Av. Diagonal 647, 08028 Barcelona, Spain.
Acta Biomater. 2010 Aug;6(8):2863-73. doi: 10.1016/j.actbio.2010.01.036. Epub 2010 Feb 1.
The key feature of calcium phosphate cements (CPCs) lies in the setting reaction triggered by mixing one or more solid calcium phosphate salts with an aqueous solution. Upon mixture, the reaction takes place through a dissolution-precipitation process which is macroscopically observed by a gradual hardening of the cement paste. The precipitation of hydroxyapatite nanocrystals at body or room temperature, and the fact that those materials can be used as self-setting pastes, have for many years been the most attractive features of CPCs. However, the need to develop materials able to sustain bone tissue ingrowth and be capable of delivering drugs and bioactive molecules, together with the continuous requirement from surgeons to develop more easily handling cements, has pushed the development of new processing routes that can accommodate all these requirements, taking advantage of the possibility of manipulating the self-setting CPC paste. It is the goal of this paper to provide a brief overview of the new processing developments in the area of CPCs and to identify the most significant achievements.
磷酸钙骨水泥（CPCs）的关键特性在于混合一种或多种固态磷酸钙盐与水溶液时引发的凝固反应。混合后，反应通过溶解-沉淀过程进行，水泥浆逐渐变硬可宏观观察到该过程。羟基磷灰石纳米晶体在体温或室温下沉淀，而且这些材料可用作自凝糊剂，这是 CPCs 多年来最具吸引力的特点。然而，需要开发能够维持骨组织长入并能够输送药物和生物活性分子的材料，同时外科医生也不断要求开发更易于操作的水泥，这推动了新加工路线的发展，这些路线可以利用操纵自凝 CPC 糊剂的可能性来满足所有这些要求。本文旨在简要概述 CPC 领域的新加工进展，并确定最显著的成果。
