The Jackson Laboratory, Bar Harbor, ME 04609, USA.
J Biomed Inform. 2011 Feb;44(1):75-9. doi: 10.1016/j.jbi.2010.01.006. Epub 2010 Feb 1.
The Cell Ontology (CL) aims for the representation of in vivo and in vitro cell types from all of biology. The CL is a candidate reference ontology of the OBO Foundry and requires extensive revision to bring it up to current standards for biomedical ontologies, both in its structure and its coverage of various subfields of biology. We have now addressed the specific content of one area of the CL, the section of the ontology dealing with hematopoietic cells. This section has been extensively revised to improve its content and eliminate multiple inheritance in the asserted hierarchy, and the groundwork has been laid for structuring the hematopoietic cell type terms as cross-products incorporating logical definitions built from relationships to external ontologies, such as the Protein Ontology and the Gene Ontology. The methods and improvements to the CL in this area represent a paradigm for improvement of the entire ontology over time.
细胞本体论（CL）旨在表示来自所有生物学的体内和体外细胞类型。CL 是 OBO 基础的候选参考本体论，需要进行广泛的修订，以使其在结构和对生物学各个子领域的涵盖范围方面达到当前生物医学本体论的标准。我们现在已经解决了 CL 的一个特定领域的具体内容，即本体论处理造血细胞的部分。这个部分已经经过了广泛的修订，以改进其内容并消除断言层次结构中的多重继承，并且已经为将造血细胞类型术语构建为交叉产品奠定了基础，这些交叉产品包含从与外部本体论（如蛋白质本体论和基因本体论）的关系构建的逻辑定义。该领域中对 CL 的方法和改进代表了随着时间的推移对整个本体论进行改进的范例。
