Unit of skin cancer, Nantes University Hospital, Place Alexis Ricordeau 44093 Cedex 01 Nantes, France.
Eur J Dermatol. 2010 Mar-Apr;20(2):172-4. doi: 10.1684/ejd.2010.0879. Epub 2010 Feb 2.
Esthetic or functional repercussions in localized scleroderma may be considerable. Numerous treatments have been proposed with limited effectiveness. The purpose of this study was to evaluate the efficacy of high-dose zinc gluconate in the treatment of morphea. We are reporting a retrospective study of 17 patients with histologically confirmed localized scleroderma active for more than one year and whose treatment with a high potency dermocorticosteroid was a failure. The patients received 60 to 90 mg of zinc metal daily. The clinical evaluation was performed by the physician and the patient. An efficacy of 53% was obtained (5 partial remissions and 4 complete remissions) with a mean dose of 83.3 mg/day of zinc metal. Two patients (11.8%) had epigastralgia; no discontinuation of zinc gluconate for poor tolerability was noted.We conclude that high-dose zinc gluconate can therefore be a valuable alternative treatment for localized scleroderma, with good tolerability, although placebo-controlled studies are necessary to confirm our results.
局限性硬皮病可能会产生美观或功能方面的影响。目前已经提出了许多治疗方法，但效果有限。本研究旨在评估高剂量葡萄糖酸锌治疗硬斑病的疗效。我们报告了一项回顾性研究，纳入了 17 名组织学证实的局限性硬皮病患者，这些患者的疾病活动期超过 1 年，且强效皮质类固醇治疗失败。患者每天接受 60 至 90 毫克的锌金属。临床评估由医生和患者共同进行。疗效评估结果为 53%（5 例部分缓解和 4 例完全缓解），锌金属的平均日剂量为 83.3 毫克。2 名患者（11.8%）出现上腹痛；未因不耐受而停用葡萄糖酸锌。我们得出结论，高剂量葡萄糖酸锌可能是局限性硬皮病的一种有价值的替代治疗方法，具有良好的耐受性，但仍需要安慰剂对照研究来证实我们的结果。
