Tu Chuqiao, Osborne Elizabeth A, Louie Angelique Y
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Tetrahedron. 2009 Feb;65(7):1241. doi: 10.1016/j.tet.2008.12.020.
A redox- and light-sensitive, T(1)-weighted magnetic resonance imaging (MRI) contrast agent which tethers a spiropyran(SP)/merocyanine(MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form which has an r(1) relaxivity of 2.51 mM(-1)s(-1) (60MHz, 37°C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r(1) relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
合成并表征了一种将螺吡喃（SP）/部花青（MC）基序与钆-二乙三胺五乙酸（Gd-DO3A）部分相连的氧化还原和光敏感的T1加权磁共振成像（MRI）造影剂。在黑暗中时，该探针处于其MC形式，其纵向弛豫率r(1)为2.51 mM-1s-1（60MHz，37°C）。在用可见光照射或与烟酰胺腺嘌呤二核苷酸（NADH）混合后，该探针发生异构化，r(1)弛豫率分别降低了18%和26%。此外，在该化合物与NADH混合后，MRI中的信号强度出现了明显下降。
