Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, Korea.
Nutr Res Pract. 2008 Spring;2(1):17-21. doi: 10.4162/nrp.2008.2.1.17. Epub 2008 Mar 31.
Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this study was to determine the bioavailability and tissue distribution of aloin. Rats were gavaged with 11.8g/kg aloin, and the levels of aloin and its conjugates were measured in plasma, tissues, and urine. Plasma aloin level showed a peak at 1hr after the administration and the concentration was 59.07+/-10.5 ng/ml. The 24 h cumulated urinary aloin was 0.03% of the initial dose. These results suggest that aloin is absorbed and reaches a peak plasma level within 1-1.5 h after the administration and a significant portion is possibly metabolized or is excreted in feces. These results can apply to the determination of the adequate intake level of aloe and aloe products to achieve the desired biological effect, and to interprete in vitro study results.
芦荟苷是芦荟中一种具有生理活性的蒽醌类化合物。芦荟苷有两种同分异构体，即芦荟苷 A 和芦荟苷 B，它们以非对映异构体混合物的形式存在。本研究旨在测定芦荟苷的生物利用度和组织分布。大鼠灌胃给予 11.8g/kg 芦荟苷，测定血浆、组织和尿液中芦荟苷及其共轭物的浓度。给药后 1 小时，血浆芦荟苷水平达到峰值，浓度为 59.07+/-10.5ng/ml。24 小时尿液中芦荟苷累积排泄量为初始剂量的 0.03%。这些结果提示，芦荟苷在给药后 1-1.5 小时内被吸收并达到血浆峰值水平，很大一部分可能在粪便中被代谢或排泄。这些结果可用于确定摄入芦荟和芦荟制品的适宜剂量以达到预期的生物学效应，并可用于解释体外研究结果。
