Chung J H, Cheong J C, Lee J Y, Roh H K, Cha Y N
College of Pharmacy, Seoul National University, Korea.
Biochem Pharmacol. 1996 Nov 8;52(9):1461-8. doi: 10.1016/s0006-2952(96)00514-x.
Aloe contains abundant aloin, a C-glycoside derivative of anthraquinone. Based on recent reports indicating that the water extract of Aloe enhances the ethanol oxidation rate and also that quinones, in general, have a functional role in elevating the alcohol oxidation rate in vivo, we have attempted to identify the quinone derivative contained in Aloe that could increase the alcohol oxidation rate. Upon oral administration of aloin (300 mg/kg) given 12 hr prior to the administration of alcohol (3.0 g/kg), the blood alcohol area under the curve (AUC) was found to be decreased significantly (by 40%). This was supported by increases in the rates of blood alcohol elimination and the disappearance of alcohol from the body by 45 and 50%, respectively. Analysis of hepatic triglyceride (TG) levels revealed that both the ethanol and the aloin treatment alone significantly increased the TG levels in a comparable manner; however, the level obtained by the combined treatment of aloin and ethanol was not statistically different from that produced by either treatment alone. The levels of serum L-aspartate:2-oxoglutarate aminotransferase (AST) and L-alanine:2-oxoglutarate aminotransferase (ALT) activities were not increased by acute alcohol intoxication, aloin alone, or by the combined treatment of alcohol and aloin. Pretreatments with aloe-emodin, the anthraquinone aglycone of aloin, resulted in a significantly decreased blood alcohol AUC and an increase in the rate of ethanol disappearance. These results suggested that when the aloin localized primarily in the skin of Aloe is ingested, aloe-emodin (the quinone aglycone) may be released, and the released quinone may produce acceleration of the ethanol metabolism rate in vivo.
芦荟含有丰富的芦荟素，一种蒽醌的C -糖苷衍生物。基于最近的报告表明芦荟水提取物可提高乙醇氧化速率，并且一般来说醌类在提高体内酒精氧化速率方面具有功能性作用，我们试图鉴定芦荟中所含的能够提高酒精氧化速率的醌类衍生物。在给予酒精（3.0 g/kg）前12小时口服芦荟素（300 mg/kg）后，发现血中酒精曲线下面积（AUC）显著降低（降低40%）。血中酒精消除速率增加以及酒精从体内消失速率分别增加45%和50%，这支持了上述结果。肝甘油三酯（TG）水平分析表明，单独给予乙醇和芦荟素均以类似方式显著提高了TG水平；然而，芦荟素和乙醇联合处理所获得的水平与单独任何一种处理所产生的水平在统计学上无差异。急性酒精中毒、单独使用芦荟素或酒精与芦荟素联合处理均未增加血清L -天冬氨酸：2 -酮戊二酸氨基转移酶（AST）和L -丙氨酸：2 -酮戊二酸氨基转移酶（ALT）的活性。用芦荟大黄素（芦荟素的蒽醌苷元）预处理导致血中酒精AUC显著降低以及乙醇消失速率增加。这些结果表明，当主要存在于芦荟叶皮中的芦荟素被摄入时，芦荟大黄素（醌苷元）可能被释放，并且释放的醌可能在体内加速乙醇代谢速率。
