von Diemen Vinicius, Trindade Manoel Roberto Maciel
Federal University of Rio Grande do Sul, Brazil.
Acta Cir Bras. 2010 Feb;25(1):37-42. doi: 10.1590/s0102-86502010000100010.
Determine the effects of the MSG (monosodium glutamate) in the offspring of pregnant rats through the comparison of the weight, NAL (nasal-anal length) and IL (Index of Lee) at birth and with 21 days of life.
Pregnant Wistar rats and their offspring were divided into 3 groups: GC, G10 and G20. Each of the groups received 0%, 10% and 20% of MSG, respectively from coupling until the end of the weaning period.
Neither weight nor NAL were different among the groups at birth. The group G20 at birth had an IL lower than the group GC (p<0,05) and with 21 days of life presented weight and NAL lower than the groups G10 and this lower than the GC (p<0,01). Otherwise the G20 at 21 days of life had the IL similar to the other two groups. The weight profit percentage from birth to the 21st day of life was lower in the G20 regarding the other two groups (p<0,01). The G20 had a NAL increase percentage from birth to the 21st day of life lower than the G10 and this lower than the GC (p<0,01).
MSG presented a dose-dependent relation in the variables weight and NAL. It caused a decrease in the growth pattern as well as in the weight gain pattern until the 21st day of life. The IL of the group 20% had an increased in relation to the control group after 3 weeks of follow up.
通过比较出生时及出生21天时的体重、鼻肛长度（NAL）和李氏指数（IL），确定味精（MSG）对怀孕大鼠后代的影响。
将怀孕的Wistar大鼠及其后代分为3组：GC组、G10组和G20组。从交配到断奶期结束，每组分别接受0%、10%和20%的味精。
出生时各组之间的体重和NAL均无差异。出生时G20组的IL低于GC组（p<0.05），出生21天时，其体重和NAL低于G10组，且低于GC组（p<0.01）。此外，出生21天时G20组的IL与其他两组相似。与其他两组相比，G20组从出生到出生21天的体重增加百分比更低（p<0.01）。G20组从出生到出生21天的NAL增加百分比低于G10组，且低于GC组（p<0.01）。
味精在体重和NAL变量上呈现剂量依赖关系。它导致生长模式以及体重增加模式下降，直至出生21天。随访3周后，20%组的IL相对于对照组有所增加。
