Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
Oncol Rep. 2010 Mar;23(3):615-9. doi: 10.3892/or_00000676.
It has been reported that the number of typtase-positive mast cells was significantly greater in breast peritumoral tissue. However, the significance of tryptase in tumor growth and metastasis is unknown. Tryptase in surgical breast cancer samples was stained by immunohistochemistry. The effects of tryptase on breast cancer proliferation, invasion and migration were observed in vitro. We found significantly more tryptase in peritumoral tissue than in normal breast tissue. The increased tryptase was associated with higher tumor grade and more lymph node metastasis. Tryptase promoted the invasion and migration of breast cancer cells along with activation of matrix metalloproteinase-2. Tryptase did not affect the proliferation of the cells. Our results indicate that tryptase promotes breast cancer migration and invasion.
据报道，在肿瘤周围组织中，类胰蛋白酶阳性肥大细胞的数量明显更多。然而，类胰蛋白酶在肿瘤生长和转移中的意义尚不清楚。免疫组织化学染色法检测手术乳腺癌样本中的类胰蛋白酶。在体外观察类胰蛋白酶对乳腺癌增殖、侵袭和迁移的影响。我们发现肿瘤周围组织中的类胰蛋白酶明显多于正常乳腺组织。增加的类胰蛋白酶与更高的肿瘤分级和更多的淋巴结转移相关。类胰蛋白酶促进了乳腺癌细胞的侵袭和迁移，同时激活了基质金属蛋白酶-2。类胰蛋白酶不影响细胞的增殖。我们的结果表明，类胰蛋白酶促进乳腺癌的迁移和侵袭。
