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骶神经刺激治疗内括约肌功能障碍相关的肛门失禁。

Sacral nerve stimulation for the treatment of faecal incontinence related to dysfunction of the internal anal sphincter.

机构信息

Physiology Unit, St Mark's Hospital, Watford Road, Harrow, London, HA1 3UJ, UK.

出版信息

Int J Colorectal Dis. 2010 May;25(5):625-30. doi: 10.1007/s00384-010-0880-2. Epub 2010 Feb 2.

Abstract

PURPOSE

In patients with faecal incontinence related to isolated internal anal sphincter (IAS) disruption, conservative management is the mainstay of treatment. Surgical repair of the internal sphincter is not successful. This study evaluated the use of sacral nerve stimulation (SNS) in those with faecal incontinence and IAS disruption in whom medical and behavioural treatments had failed.

METHODS

Nine patients (seven women, median age 44 years, range 39-62 years), with a history of obstetric or iatrogenic anal sphincter trauma, underwent a trial of SNS. All had passive faecal incontinence, low resting anal sphincter pressure and full thickness IAS muscle disruption of greater than 30 degrees radial extent. The effect of SNS on symptoms was measured by a bowel habit diary and validated questionnaires used to assess impact on quality of life.

RESULTS

Eight (89%) patients benefited from temporary stimulation and proceeded to permanent device implantation. Follow-up was at a mean of 46 months (range 2-81). Faecal incontinence decreased from a mean (SD) of 9.9 (10.9) to 1.0 (2.4) episodes per week (p = 0.031), and soiling decreased from 6.1 (1.6) to 1.7 (2.4) episodes per week (p = 0.031), with chronic stimulation. At latest follow-up, three patients had no incontinence, three patients had episodes of minor soiling only, one patient had >75% reduction of incontinent episodes, and two patients remained incontinent.

CONCLUSIONS

Sacral nerve stimulation is effective in treating faecal incontinence related to a structurally and functionally abnormal internal anal sphincter. Treatment should not be refused on the basis of IAS disruption.

摘要

目的

在因孤立性内肛门括约肌(IAS)破裂而导致粪便失禁的患者中,保守治疗是主要治疗方法。内括约肌的手术修复并不成功。本研究评估了在那些因医源性或产科性肛门括约肌创伤而导致内括约肌破裂且药物和行为治疗失败的患者中使用骶神经刺激(SNS)的效果。

方法

9 名患者(7 名女性,中位年龄 44 岁,范围 39-62 岁),有产科或医源性肛门括约肌创伤史,接受了 SNS 试验。所有患者均有被动性粪便失禁、静息肛门括约肌压力低以及全层 IAS 肌肉破裂大于 30 度的放射范围。SNS 对症状的影响通过排便习惯日记和用于评估对生活质量影响的有效问卷进行测量。

结果

8 名(89%)患者得益于临时刺激,并继续进行永久性设备植入。平均随访时间为 46 个月(范围 2-81 个月)。粪便失禁从平均(SD)9.9(10.9)次/周降至 1.0(2.4)次/周(p=0.031),污染从 6.1(1.6)次/周降至 1.7(2.4)次/周(p=0.031),慢性刺激时。在最近的随访中,3 名患者无失禁,3 名患者仅偶尔有轻度污染,1 名患者失禁次数减少超过 75%,2 名患者仍失禁。

结论

骶神经刺激对内肛门括约肌结构和功能异常导致的粪便失禁有效。不应该因为 IAS 破裂而拒绝治疗。

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