Pharmacology Program, Faculty of Medicine, ICBM, Universidad de Chile, Clasificador 70.000, Independencia 1027, Santiago, 7, Chile.
Inflammopharmacology. 2010 Apr;18(2):65-71. doi: 10.1007/s10787-009-0019-7. Epub 2010 Feb 2.
The antinociception induced by the intraperitoneal coadministration in mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and orofacial formalin test.
The antinociception of each drugs alone and the interaction of the combinations was evaluated by isobolographic analysis in the tail-flick and in the formalin orofacial assay of mice.
Mice pretreated with the drugs demonstrated that the antinociception of metamizol and paracetamol is dose-dependent. The potency range on the antinocifensive responses for metamizol or paracetamol was as follows: orofacial (Phase II) > orofacial (Phase I) > tail flick. In addition, the coadministration of metamizol with paracetamol induced a strong synergistic antinociception in the algesiometer assays. Both drugs showed effectiveness in inflammatory pain.
These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.
在小鼠的腹腔内同时给予甲灭酸和扑热息痛，评估其在尾巴敲击试验和口腔福尔马林试验中引起的镇痛作用。
通过等辐射分析评估单独使用药物和组合药物的相互作用对尾巴敲击和口腔福尔马林试验中产生的镇痛作用。
用药物预处理的小鼠表明，甲灭酸和扑热息痛的镇痛作用呈剂量依赖性。甲灭酸或扑热息痛对镇痛反应的效价范围如下：口腔（第二相）>口腔（第一相）>尾巴敲击。此外，甲灭酸与扑热息痛联合给药在疼痛计测定中引起强烈的协同镇痛作用。两种药物均对炎性疼痛有效。
这些作用可能与药物对 COX 同工酶抑制的不同选择性有关，也可能与镇痛药物在疼痛传递中启动的几种额外的镇痛机制和途径有关。由于本研究已经证明了甲灭酸与扑热息痛的组合的疗效，因此这种联合可能对临床疼痛的药物治疗有潜在的有益作用。
