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金化合物在 HIV 治疗方面的可能性。

HIV therapeutic possibilities of gold compounds.

机构信息

Department of Biochemistry, University of Pretoria, Hatfield Campus, Pretoria 0002, South Africa.

出版信息

Biometals. 2010 Apr;23(2):185-96. doi: 10.1007/s10534-010-9293-5. Epub 2010 Feb 3.

Abstract

Highly active antiretroviral therapy (HAART) has resulted in decreased mortality and morbidity from the acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). Drug resistance and toxicity of HAART has led to the search for novel inhibitors of HIV infection. Gold-based compounds have shown promising activity against a wide range of clinical conditions and microorganism infections including HIV-1. A typical example is auranofin which resulted in an elevated CD4+ T-cell count in an HIV patient being treated for psoriatic arthritis. In addition, reports exist on gold-based inhibitors of reverse transcriptase (RT), protease (PR) and viral entry of host cells. These and other characteristics of gold-based HIV drugs are reviewed here.

摘要

高效抗逆转录病毒疗法(HAART)降低了由人类免疫缺陷病毒(HIV)引起的获得性免疫缺陷综合征的死亡率和发病率。HAART 的耐药性和毒性导致人们寻找新型 HIV 感染抑制剂。金基化合物在治疗包括 HIV-1 在内的广泛临床病症和微生物感染方面显示出良好的活性。一个典型的例子是金诺芬,它可使接受银屑病关节炎治疗的 HIV 患者的 CD4+T 细胞计数升高。此外,还有关于金基逆转录酶(RT)、蛋白酶(PR)和宿主细胞病毒进入抑制剂的报告。本文综述了金基 HIV 药物的这些和其他特性。

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