Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Bioessays. 2010 Mar;32(3):207-217. doi: 10.1002/bies.200900105.
Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration.
许多动物表现出组织甚至完整身体的再生能力。再生生物学的主要目标之一是鉴定出该过程所需的基因和遗传网络。果蝇为这类研究提供了一个理想的模式系统。广泛可用的遗传和基因组方法有助于启动对再生机制的解析，并且这些结果可能适用于包括哺乳动物在内的其他生物体。此外，大多数再生模型都需要实验操作，而在果蝇中，通过遗传诱导方法可以切除离散的区域。在这里，我们总结了当前关于成虫盘再生的研究，并讨论了该组织作为理解再生遗传学工具的强大功能。
