Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Development. 2020 Apr 6;147(7):dev173781. doi: 10.1242/dev.173781.
has historically been a workhorse model organism for studying developmental biology. In addition, is an excellent model for studying how damaged tissues and organs can regenerate. Recently, new precision approaches that enable both highly targeted injury and genetic manipulation have accelerated progress in this field. Here, we highlight these techniques and review examples of recently discovered mechanisms that regulate regeneration in larval and adult tissues. We also discuss how, by applying these powerful approaches, studies of can continue to guide the future of regeneration research.
一直以来都是研究发育生物学的主力模式生物。此外，还是研究受损组织和器官如何再生的绝佳模型。最近，新的精确方法使高度靶向损伤和基因操作成为可能，从而加速了这一领域的进展。在这里，我们重点介绍这些技术，并回顾最近发现的调节 幼虫和成年组织再生的机制的例子。我们还讨论了如何通过应用这些强大的方法，使对 的研究继续指导再生研究的未来。
