Biomedical Engineering, School of AMME J07, University of Sydney, Sydney, Australia.
J Biomed Mater Res B Appl Biomater. 2010 Apr;93(1):285-95. doi: 10.1002/jbm.b.31588.
Synthetic graft materials are emerging as a viable alternative to autogenous bone graft and bone allograft for the treatment of critical-sized bone defects. These materials can be osteoconductive but are rarely intrinsically osteogenic, although this can be greatly enhanced by the application of bone morphogenetic proteins (BMPs). This review will discuss the versatility of biodegradable poly(alpha-hydroxy acids) for the delivery of BMPs for bone tissue engineering. Poly(alpha-hydroxy acids) have a considerable potential for customization and adaptability via modification of design parameters, including scaffold architecture, composition, and biodegradability. Different fabrication techniques will also be discussed.
合成移植物材料作为自体骨移植物和同种异体骨移植物的可行替代品，正逐渐应用于治疗临界尺寸骨缺损。这些材料具有骨传导性，但很少具有内在成骨性，尽管通过应用骨形态发生蛋白（BMPs）可以极大地增强其成骨性。本综述将讨论可生物降解的聚（α-羟基酸）在骨组织工程中递送 BMP 的多功能性。通过改变设计参数，包括支架结构、组成和生物降解性，聚（α-羟基酸）具有相当大的定制化和适应性潜力。不同的制造技术也将进行讨论。
