Chocholata Petra, Kulda Vlastimil, Babuska Vaclav
Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Pilsen, Czech Republic.
Materials (Basel). 2019 Feb 14;12(4):568. doi: 10.3390/ma12040568.
The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration.
本文描述了骨组织工程这个快速发展领域的当前技术水平，在该领域中，材料科学、机械工程、临床医学和遗传学等许多学科相互关联。主要目标是通过支架恢复和改善骨组织的功能，为组织再生和修复提供适宜的环境。口腔再生治疗中使用的策略和材料与骨组织工程中普遍使用的技术相对应。研究人员正致力于开发和改进新材料，以尽可能逼真地模拟天然生物微环境。最有前景的是细胞与基质（支架）的组合，这种组合可以由不同种类的材料制成。这篇综述总结了目前可用于骨组织再生的支架材料和制造技术。
