微小 RNA、巴雷特食管的发育和食管腺癌的进展。
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
出版信息
World J Gastroenterol. 2010 Feb 7;16(5):531-7. doi: 10.3748/wjg.v16.i5.531.
Abstract
Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esophageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is becoming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer.
摘要
巴雷特食管是一种由胃食管反流引起的癌前病变。一旦发生，它可以通过不同程度的异型增生进展为食管腺癌。虽然人们普遍认为巴雷特食管是由胃食管反流引起的，但它的发病机制和进展为癌症的分子机制仍不清楚。 microRNAs（miRNAs）是短的 RNA 片段，已经被证明可以控制许多人类基因的表达。它们参与了大多数细胞过程，miRNAs 在疾病发展中的作用也越来越明显。了解 miRNA 表达的改变可能有助于揭示支持巴雷特食管发展及其进展为癌症的分子机制。
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