Peng Lina, Shan Chunguang, Feng Zhixing, Yang Lihui
Department of Otolaryngology, the Central Hospital of Handan, Handan, 056000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Mar;27(5):264-6.
To explore the expression and significance of survivin and proliferating cell nuclear antigen (PCNA) on the occurrence, proliferation, recurrence and carcinogenesis of the sinonasal inverted papilloma (SNIP).
Immunohistochemical method was used to detect the expression of survivin and PCNA in 10 cases of nasal cavity mucosal (NM), 45 cases of SNIP and 9 cases of canceration SNIP.
The positive expression of survivin and PCNA increased gradually in NM,SNIP and canceration PCNA group, and there were significant difference between the three groups. But there was no correlation between survivin and PCNA in the tissue of SNIP (r = 0.135, P > 0.05).
Survivin and PCNA are involved in the growth and carcinogenesis of SNIP.
探讨生存素（survivin）和增殖细胞核抗原（PCNA）在鼻腔鼻窦内翻性乳头状瘤（SNIP）发生、增殖、复发及癌变中的表达及意义。
采用免疫组织化学方法检测10例鼻腔黏膜（NM）、45例SNIP及9例癌变SNIP中survivin和PCNA的表达。
survivin和PCNA的阳性表达在NM、SNIP及癌变SNIP组中逐渐升高，三组间差异有统计学意义。但SNIP组织中survivin与PCNA无相关性（r = 0.135，P > 0.05）。
Survivin和PCNA参与了SNIP的生长及癌变过程。
