Falasca Francesca, Maida Paola, Boni Arianna, Bernardi Stefania, Cursi Laura, Rizzo Bambina, Antonelli Guido, Gattinara Guido Castelli, Turriziani Ombretta
Department of Experimental Medicine, Virology Section, "Sapienza" University of Rome, Italy.
New Microbiol. 2009 Oct;32(4):411-3.
It has been demonstrated that HIV infection may affect the levels of thymidine kinase (TK) and deoxycytidine kinase (dCK) in peripheral blood mononuclear cells from HIV infected adults. The aim of this study was to examine the effect of HIV infection and/or antiretroviral therapy on the activity of the above enzymes in HIV-infected children. The results showed that an inter-individual variability in TK and dCK activities does exist in both HIV infected and uninfected children. TK and dCK levels in PBMC from HIV infected and non infected children did not significantly differ. Furthermore, the therapeutic regimen, including zidovudine, does not seem to affect TK activity.
已经证明，HIV感染可能会影响HIV感染成年人外周血单核细胞中胸苷激酶（TK）和脱氧胞苷激酶（dCK）的水平。本研究的目的是检查HIV感染和/或抗逆转录病毒疗法对HIV感染儿童上述酶活性的影响。结果表明，HIV感染儿童和未感染儿童中TK和dCK活性确实存在个体间差异。HIV感染儿童和未感染儿童外周血单核细胞中的TK和dCK水平没有显著差异。此外，包括齐多夫定在内的治疗方案似乎不会影响TK活性。
