角膜胶原交联术联合核黄素和 UVA 照射治疗后弹力层营养不良
Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration.
机构信息
Department of Surgical Sciences, Eye Clinic, University of L'Aquila, Italy.
出版信息
J Refract Surg. 2010 May;26(5):375-7. doi: 10.3928/1081597X-20100114-03.
PURPOSE
To report the results of corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A irradiation in a patient affected by pellucid marginal degeneration (PMD).
METHODS
A 43-year-old man with bilateral PMD underwent CXL in the left eye. The treatment was performed in standard fashion with the exception of slightly inferior decentration of the 9 mm-diameter irradiated area preserving an untreated surface area 1 mm from the limbus.
RESULTS
Epithelial regrowth was complete after 4 days' use of a bandage soft contact lens. No side effects or damage to the limbal region were observed during re-epithelialization or during follow-up. Corrected distance visual acuity improved from 20/200 to 20/63 at 3 months and was stable through the 12-month interval. Keratometric astigmatism showed a 1.40-diopter (D) reduction and the power of ectasia apex decreased from 82.00 D to 78.00 D.
CONCLUSIONS
Corneal collagen CXL was a safe tool in the management of PMD, improving some parameters in advanced stages of the disease.
目的
报告一例边缘性角膜营养不良（PMD）患者行核黄素和紫外线 A 照射交联（CXL）的结果。
方法
一名 43 岁男性，双眼均患有 PMD，左眼行 CXL。治疗按标准方式进行，仅 9mm 直径的照射区轻度偏心，保留 1mm 未处理的边缘区。
结果
术后 4 天佩戴绷带软性角膜接触镜，上皮完全再生。在再上皮化或随访过程中，均未观察到边缘区的任何副作用或损伤。矫正远视力从 20/200 提高到 3 个月时的 20/63，并在 12 个月的随访中保持稳定。角膜散光屈光度降低 1.40 屈光度（D），扩张顶点的力量从 82.00D 降低到 78.00D。
结论
角膜胶原 CXL 是 PMD 管理的一种安全工具，可改善疾病晚期的一些参数。
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