Wallace Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA.
J Neuroinflammation. 2010 Feb 3;7:10. doi: 10.1186/1742-2094-7-10.
This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.
After a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.
The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research.
本文综述了与神经炎症性疾病相关的血小板生物学的最新进展。多发性硬化症（MS）被视为此类疾病的“典型代表”，但其影响广泛。血小板在心血管和癌症研究领域的炎症作用已得到充分认识，但在神经学研究中似乎相对被忽视。
在简要介绍血小板后，涵盖的主题包括基质金属蛋白酶、血小板趋化因子、细胞因子和生长因子、最近发现的血小板 PPAR 受体和 Toll 样受体、补体、生物活性脂质以及其他可能与神经炎症性疾病相关的药物/功能。每个部分都引用了将该主题与 MS 或其他疾病（包括阿尔茨海默病）的活跃研究领域联系起来的文献。
最后一节总结了血小板参与 MS 的证据。总的结论是，血小板可能是 MS 及相关疾病的关键参与者，值得在神经学研究中给予更多关注。
