Endler Pc, Thieves K, Reich C, Matthiessen P, Bonamin L, Scherr C, Baumgartner S
Interuniversity College for Health and Development Graz/Castle of Seggau, Austria.
Homeopathy. 2010 Jan;99(1):25-36. doi: 10.1016/j.homp.2009.11.008.
Repeatability of experiments is an important criterion of modern research and a major challenge for homeopathic basic research. There is no recent overview about basic research studies in high homeopathic potencies that have been subjected to laboratory-internal, multicenter or independent repetition trials.
We considered biochemical, immunological, botanical, cell biological and zoological studies on high potencies, i.e. beyond a dilution of 10(-23). Main sources of information were reviews, personal contact with members of the homeopathic basic research community, and the MEDLINE and HOMBREX databases. Studies were extracted from the publications and grouped into models. Studies were further sorted according to repetition type (laboratory-internal, multicenter, or independent) and results achieved.
A total of 107 studies were found. Of these, 30 were initial studies. In the attempt to reproduce one of these initial studies, 53 follow-up studies yielded comparable effects (35 laboratory-internal, 8 multicenter, 10 independent repetitions), eight studies showed a consistent, yet different result from the initial study (2 laboratory-internal, 2 multicenter, 4 independent repetitions), and 16 studies yielded no effects (5 laboratory-internal, 2 multicenter, 9 independent repetitions). When all repetitive studies are considered, 69% reported effects comparable to that of the initial study, 10% different effects, and 21% no effects. Independently performed repetition studies reported 44% comparable effects, 17% different effects, and 39% no effects.
We identified 24 experimental models in basic research on high homeopathic potencies, which were repeatedly investigated. 22 models were reproduced with comparable results, 6 models with different results, and repetition showed no results for 15 models. Independent reproductions with either comparable or different results were found for seven models. We encourage further repetition trials of published studies, in order to learn more about the model systems used and in order to test their repeatability.
实验的可重复性是现代研究的一项重要标准，也是顺势疗法基础研究面临的一项重大挑战。目前尚无关于高稀释度顺势疗法效力的基础研究的近期综述，这些研究已经历了实验室内部、多中心或独立重复试验。
我们考虑了关于高稀释度（即超过10^(-23)稀释度）的生化、免疫、植物学、细胞生物学和动物学研究。主要信息来源包括综述、与顺势疗法基础研究领域成员的个人交流以及MEDLINE和HOMBREX数据库。从出版物中提取研究并按模型进行分组。研究进一步根据重复类型（实验室内部、多中心或独立）和所取得的结果进行分类。
共找到107项研究。其中，30项为初始研究。在试图重复其中一项初始研究时，53项后续研究产生了可比效应（35项实验室内部重复、8项多中心重复、10项独立重复），8项研究显示出与初始研究一致但不同的结果（2项实验室内部重复、2项多中心重复、4项独立重复），16项研究未产生效应（5项实验室内部重复、2项多中心重复、9项独立重复）。当考虑所有重复性研究时，69%报告的效应与初始研究可比，10%报告不同效应，21%未产生效应。独立进行的重复研究报告44%的可比效应、17%的不同效应和39%的无效应。
我们在高稀释度顺势疗法效力的基础研究中确定了24个实验模型，这些模型已被反复研究。22个模型得到了具有可比结果的重复，6个模型得到了不同结果的重复，15个模型的重复未得到结果。7个模型有可比或不同结果的独立重复。我们鼓励对已发表的研究进行进一步的重复试验，以便更多地了解所使用的模型系统，并测试其可重复性。
