Department of Biotechnology, University of Rijeka, Croatia.
Funct Integr Genomics. 2010 Mar;10(1):11-9. doi: 10.1007/s10142-010-0159-2. Epub 2010 Feb 4.
Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the "omics". Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.
乳腺癌是一种复杂且异质的疾病。经典的分子医学方法无法完全理解和领会其发病机制。在这篇综述中，根据“组学”的快速发展，讨论了用于早期检测和创建乳腺癌靶向和特异性治疗的新生物标志物的发展。癌症研究的结果与大规模的方法相结合，这些方法检查了基因和蛋白质的表达状态，确定了大量新的生物标志物，并通过其自分泌调节确认了人类生长激素是该疾病发病机制中的一个重要参与者，因为它影响 Pax5 和 HOXA1 基因网络的激活。
