School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.
J Am Chem Soc. 2010 Mar 3;132(8):2508-9. doi: 10.1021/ja909984w.
Although recent advances in dynamic nuclear polarization techniques have boosted the otherwise low sensitivity of NMR spectroscopy, the efficiency of the hyperpolarization process depends on the composition of the polarization matrix, in particular on the contact between the radical and the target molecule and the capability of the matrix to transfer polarization through spin diffusion. A concept for optimal matrix design is presented, applied to obtain two-dimensional heterocorrelated spectra of small drug-like molecules in 1-2 min after 90 min of hyperpolarization.
尽管最近动态核极化技术的进步提高了 NMR 光谱原本较低的灵敏度，但超极化过程的效率取决于极化矩阵的组成，特别是自由基与靶分子的接触以及矩阵通过自旋扩散传递极化的能力。提出了一种优化矩阵设计的概念，并将其应用于在 90 分钟超极化后 1-2 分钟内获得小分子药物的二维异相关谱。
