Frijia Francesca, Flori Alessandra, Giovannetti Giulio, Barison Andrea, Menichetti Luca, Santarelli Maria Filomena, Positano Vincenzo
Bioengineering Unit, Fondazione Toscana G. Monasterio, 56124 Pisa, Italy.
Institute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Diagnostics (Basel). 2024 May 17;14(10):1035. doi: 10.3390/diagnostics14101035.
Cardiovascular disease shows, or may even be caused by, changes in metabolism. Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could assess the role of different aspects of metabolism in heart disease, allowing real-time metabolic flux assessment in vivo. In this review, we introduce the main hyperpolarization techniques. Then, we summarize the use of dedicated radiofrequency C coils, and report a state of the art of C data acquisition. Finally, this review provides an overview of the pre-clinical and clinical studies on cardiac metabolism in the healthy and diseased heart. We furthermore show what advances have been made to translate this technique into the clinic in the near future and what technical challenges still remain, such as exploring other metabolic substrates.
心血管疾病表现出代谢变化，甚至可能由代谢变化引起。超极化磁共振波谱和成像技术可以评估代谢的不同方面在心脏病中的作用，从而在体内进行实时代谢通量评估。在本综述中，我们介绍了主要的超极化技术。然后，我们总结了专用射频C线圈的使用情况，并报告了C数据采集的技术现状。最后，本综述概述了健康心脏和患病心脏心脏代谢的临床前和临床研究。我们还展示了在不久的将来将该技术转化为临床应用所取得的进展以及仍然存在的技术挑战，例如探索其他代谢底物。
