Dehghani Khatereh, Shojaie Mohammad, Pourdavood Amir Hossein, Khajouei Mohammad
Department of Cardiology, Jahrom University of Medical Sciences, Jahrom, Iran.
Cardiology Department, Non-communicable Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Arch Acad Emerg Med. 2019 Mar 9;7(1):e22. eCollection 2019.
Methadone poisoning has become more common in the pediatric population due to extensive use of methadone maintenance therapy (MMT). It is associated with decreased level of consciousness, coma, respiratory distress and cardiac intoxication. The cardiac complications have been reported to be QT prolongation, torsade de pointes, coronary artery disease, arrhythmia, stress cardiomyopathy and death. We herein report two pediatric patients with accidental methadone poisoning who developed stress cardiomyopathy and cardiac failure. The first case was a 4-yaer-old girl and the second one was an 18-month-old girl both being accidentally poisoned with methadone syrup and were brought with decreased level of consciousness. Both were diagnosed to suffer from congestive heart failure based on echocardiography. However, the first case passed away despite appropriate treatment, while the second one survived the condition and was discharged with good condition and was symptom free at 6-month follow-up.
由于美沙酮维持治疗（MMT）的广泛使用，美沙酮中毒在儿科人群中变得更加常见。它与意识水平下降、昏迷、呼吸窘迫和心脏中毒有关。据报道，心脏并发症包括QT间期延长、尖端扭转型室速、冠状动脉疾病、心律失常、应激性心肌病和死亡。我们在此报告两名意外美沙酮中毒的儿科患者，他们出现了应激性心肌病和心力衰竭。第一例是一名4岁女孩，第二例是一名18个月大的女孩，两人均意外服用美沙酮糖浆，因意识水平下降被送来就诊。根据超声心动图检查，两人均被诊断为患有充血性心力衰竭。然而，第一例患者尽管接受了适当治疗仍去世，而第二例患者病情好转并出院，在6个月的随访中无症状。
