Bergan T, da Fonseca J
Department of Microbiology, University of Oslo, Norway.
Chemotherapy. 1991;37(1):43-9. doi: 10.1159/000238831.
The minimum inhibitory concentration (MIC) of cefcanel, a new oral cephalosporin, has been tested against 153 staphylococci subdivided into the species Staphylococcus aureus. S. epidermidis sensu lato and S. saprophyticus, with and without beta-lactamase production. The concentration inhibiting 50% of the strains was 0.5 mg/l for all three species while the corresponding values for 90% of the strains were 1, 2 and 1 mg/l, respectively. These values apply to all the strains. The MICs of the non-beta-lactamase-producing strains were identical to the MICs of the beta-lactamase-producing strains for S. aureus, three twofold steps lower for S. epidermidis and one step higher for S. saprophyticus. Consequently, beta-lactamase production had no consistent consequences for the activity of cefcanel against S. aureus and S. saprophyticus. In contrast, the beta-lactamase production of S. epidermidis did influence the activity of cefcanel. Among the tested cephalosporins, cefcanel had the highest antistaphylococcal activity, and no strain was resistant to this new cephalosporin.
新型口服头孢菌素头孢卡奈的最低抑菌浓度（MIC）已针对153株葡萄球菌进行了测试，这些葡萄球菌被细分为金黄色葡萄球菌、广义表皮葡萄球菌和腐生葡萄球菌，包括产β-内酰胺酶和不产β-内酰胺酶的菌株。对于所有这三个菌种，抑制50%菌株生长的浓度均为0.5mg/l，而对于90%菌株的相应值分别为1mg/l、2mg/l和1mg/l。这些值适用于所有菌株。对于金黄色葡萄球菌，不产β-内酰胺酶菌株的MIC与产β-内酰胺酶菌株的MIC相同；对于表皮葡萄球菌，不产β-内酰胺酶菌株的MIC比产β-内酰胺酶菌株低两个两倍稀释度；对于腐生葡萄球菌，不产β-内酰胺酶菌株的MIC比产β-内酰胺酶菌株高一个稀释度。因此，产β-内酰胺酶对头孢卡奈针对金黄色葡萄球菌和腐生葡萄球菌的活性没有一致的影响。相比之下，表皮葡萄球菌产β-内酰胺酶确实会影响头孢卡奈的活性。在所测试的头孢菌素中，头孢卡奈具有最高的抗葡萄球菌活性，且没有菌株对这种新型头孢菌素耐药。
