Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284-2018, USA.
Psychol Med. 2010 Nov;40(11):1899-906. doi: 10.1017/S0033291710000139. Epub 2010 Feb 5.
Recent behavioral genetic studies have emphasized the importance of investigating eating disorders at the level of individual symptoms, rather than as overall diagnoses. We examined the heritability of binge eating disorder (BED) using an item-factor analytic approach, which estimates contributions of additive genetic (A), common environmental (C), and unique environmental (E) influences on liability to BED as well as individual symptoms.
Participants were 614 monozygotic and 410 dizygotic same-sex female twins from the Mid-Atlantic Twin Registry who completed a self-report measure of BED symptoms based upon DSM-IV criteria. Genetic and environmental contributions to BED liability were assessed at the diagnostic and symptom levels, using an item-factor approach.
Liability to BED was moderately heritable; 45% of the variance was due to A, with smaller proportions due to C (13%), and E (42%). Additive genetic effects accounted for 29-43% of the variance in individual items, while only 8-14% was due to C.
Results highlight the relevance of examining eating disorders at the symptom level, rather than focusing on aggregate diagnoses.
最近的行为遗传学研究强调了在个体症状层面而非整体诊断层面研究饮食失调的重要性。我们采用项目因素分析方法,研究了暴食障碍(BED)的遗传性,该方法可估计暴食障碍的易感性以及个体症状受加性遗传(A)、共同环境(C)和独特环境(E)影响的程度。
参与者为来自大西洋中部双胞胎登记处的 614 对同性别双胞胎和 410 对异性别双胞胎,她们均完成了基于 DSM-IV 标准的暴食障碍症状的自我报告量表。采用项目因素分析法,在诊断和症状水平上评估暴食障碍易感性的遗传和环境贡献。
暴食障碍的易感性为中度遗传;A 解释了 45%的变异,C(13%)和 E(42%)的解释较小。加性遗传效应解释了个体项目变异的 29-43%,而 C 仅解释了 8-14%。
结果强调了在症状层面而非综合诊断层面研究饮食失调的相关性。