School of Medicine, Department of Pathology, University of São Paulo, São Paulo, Brazil.
Epilepsy Behav. 2010 Mar;17(3):324-31. doi: 10.1016/j.yebeh.2009.11.015. Epub 2010 Feb 4.
The relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. The pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. The aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep-wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxical sleep. The architecture of the sleep-wake phases was altered in epileptic rats, as was the integrity of the SWC. Because our findings reproduce many relevant features observed in patients with epilepsy, this model is suitable to study sleep dysfunction in epilepsy.
睡眠与癫痫之间的关系既复杂又具有重要的临床意义。颞叶癫痫（TLE）影响睡眠结构，而睡眠在促进和/或抑制可能的癫痫发作方面起着重要作用。匹罗卡品实验模型再现了人类颞叶癫痫的多种特征，是基础研究中应用最广泛的模型之一。本研究旨在通过行为和电生理方法来描述匹罗卡品诱导癫痫的雄性大鼠的睡眠-觉醒周期（SWC）各阶段的特征。癫痫大鼠在 SWC 的所有阶段均出现棘波，以及在警觉性觉醒和反常睡眠时出现非典型皮质同步化。癫痫大鼠的睡眠-觉醒阶段结构发生改变，SWC 的完整性也受到破坏。由于我们的发现再现了许多在癫痫患者中观察到的相关特征，因此该模型适合研究癫痫中的睡眠功能障碍。
