蛋白质 S-亚硝基化与心脏保护。
Protein S-nitrosylation and cardioprotection.
机构信息
Translational Medicine Branch, NHLBI, NIH, 10 Center Dr, Room 7N112, Bethesda, MD 20892, USA.
出版信息
Circ Res. 2010 Feb 5;106(2):285-96. doi: 10.1161/CIRCRESAHA.109.209452.
Abstract
Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group. There are emerging data suggesting that S-nitrosylation of proteins plays an important role in cardioprotection. Protein S-nitrosylation not only leads to changes in protein structure and function but also prevents these thiol(s) from further irreversible oxidative/nitrosative modification. A better understanding of the mechanism regulating protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportunities and targets for interventions in cardiovascular diseases.
摘要
一氧化氮（NO）在心血管功能调节中发挥着重要作用。除了经典的依赖 cGMP 的途径激活 NO 外，NO 还可以通过蛋白质 S-亚硝基化来调节细胞功能，这是一种依赖氧化还原、基于巯基、可逆的翻译后蛋白质修饰，涉及将 NO 部分附着到亲核蛋白质巯基基团上。有新出现的数据表明，蛋白质 S-亚硝基化在心脏保护中起着重要作用。蛋白质 S-亚硝基化不仅导致蛋白质结构和功能的变化，而且还防止这些巯基进一步发生不可逆的氧化/亚硝化修饰。更好地了解调节蛋白质 S-亚硝基化的机制及其在心脏保护中的作用，将为我们提供新的治疗机会和干预心血管疾病的靶点。
相似文献
1
Protein S-nitrosylation and cardioprotection.蛋白质 S-亚硝基化与心脏保护。
Circ Res. 2010 Feb 5;106(2):285-96. doi: 10.1161/CIRCRESAHA.109.209452.
2
S-nitrosylation: NO-related redox signaling to protect against oxidative stress.S-亚硝基化：与一氧化氮相关的氧化还原信号传导以抵御氧化应激。
Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1693-705. doi: 10.1089/ars.2006.8.1693.
3
S-nitrosylation: an emerging redox-based post-translational modification in plants.S-亚硝基化：植物中一种新出现的基于氧化还原的翻译后修饰
J Exp Bot. 2006;57(8):1777-84. doi: 10.1093/jxb/erj211. Epub 2006 May 19.
4
Protein S-nitrosylation: a role of nitric oxide signaling in cardiac ischemic preconditioning.蛋白质S-亚硝基化：一氧化氮信号在心脏缺血预处理中的作用
Sheng Li Xue Bao. 2007 Oct 25;59(5):544-52.
5
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.通过多聚S-亚硝基化激活心脏钙释放通道（雷诺丁受体）。
Science. 1998 Jan 9;279(5348):234-7. doi: 10.1126/science.279.5348.234.
6
Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics.通过硫醇氧化还原蛋白质组学鉴定神经干细胞中 S-亚硝基化的新靶标。
Redox Biol. 2020 May;32:101457. doi: 10.1016/j.redox.2020.101457. Epub 2020 Feb 7.
7
S-Nitrosylation in plants: pattern and function.植物中的 S-亚硝基化：模式与功能。
J Proteomics. 2009 Nov 2;73(1):1-9. doi: 10.1016/j.jprot.2009.07.002. Epub 2009 Jul 17.
8
TRAP1 S-nitrosylation as a model of population-shift mechanism to study the effects of nitric oxide on redox-sensitive oncoproteins.TRAP1 的 S-亚硝基化作为一种研究一氧化氮对氧化还原敏感的癌蛋白影响的种群转移机制的模型。
Cell Death Dis. 2023 Apr 21;14(4):284. doi: 10.1038/s41419-023-05780-6.
9
Expanding roles for S-nitrosylation in the regulation of plant immunity.S-亚硝基化在植物免疫调节中的作用不断扩展。
Free Radic Biol Med. 2023 Jan;194:357-368. doi: 10.1016/j.freeradbiomed.2022.12.009. Epub 2022 Dec 10.
10
Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the Heart.一氧化氮合酶1通过心脏快速且可逆的氧化还原依赖性S-亚硝基化调节基础和β-肾上腺素能刺激的收缩性。
PLoS One. 2016 Aug 16;11(8):e0160813. doi: 10.1371/journal.pone.0160813. eCollection 2016.
引用本文的文献
1
S-nitrosylation of cardiac myocyte proteins may underlie sex differences in cardiac disease.心肌细胞蛋白的S-亚硝基化可能是心脏疾病性别差异的潜在原因。
Front Physiol. 2025 May 6;16:1565917. doi: 10.3389/fphys.2025.1565917. eCollection 2025.
2
Allosteric Modulation of SERCA Pumps in Health and Disease: Structural Dynamics, Posttranslational Modifications, and Therapeutic Potential.健康与疾病中肌浆网Ca2+-ATP酶泵的变构调节：结构动力学、翻译后修饰及治疗潜力
J Mol Biol. 2025 May 9:169200. doi: 10.1016/j.jmb.2025.169200.
3
A Fluorescent Probe for Imaging and Treating S-Nitrosation Stress in OGD/R Cells.一种用于成像和治疗氧糖剥夺/复氧（OGD/R）细胞中S-亚硝基化应激的荧光探针。
Antioxidants (Basel). 2025 Mar 4;14(3):311. doi: 10.3390/antiox14030311.
4
Nitric oxide facilitates the S-nitrosylation and deubiquitination of Notch1 protein to maintain cancer stem cells in human NSCLC.一氧化氮促进 Notch1 蛋白的 S-亚硝基化和去泛素化，以维持人非小细胞肺癌中的癌症干细胞。
J Cell Mol Med. 2024 Nov;28(21):e70203. doi: 10.1111/jcmm.70203.
5
Cardiovascular events in crush syndrome: on-site therapeutic strategies and pharmacological investigations.挤压综合征中的心血管事件：现场治疗策略与药理学研究
Front Pharmacol. 2024 Sep 20;15:1472971. doi: 10.3389/fphar.2024.1472971. eCollection 2024.
6
HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis.HBB 通过干扰 ABHD5/AMPK/HDAC4 轴导致小鼠对乌头碱诱导的心脏毒性具有个体差异性。
Acta Pharmacol Sin. 2024 Jun;45(6):1224-1236. doi: 10.1038/s41401-023-01206-3. Epub 2024 Mar 11.
7
The Case for, and Challenges of, Human Cardiac Tissue in Advancing Phosphoprotein Research.人心脏组织在推进磷酸化蛋白研究中的作用及挑战
Front Physiol. 2022 Mar 23;13:853511. doi: 10.3389/fphys.2022.853511. eCollection 2022.
8
Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection.线粒体中蛋白质 S-亚硝基化增加：运动诱导心脏保护的关键机制。
Basic Res Cardiol. 2021 Dec 23;116(1):66. doi: 10.1007/s00395-021-00906-3.
9
GSNOR regulates cardiomyocyte differentiation and maturation through protein S-nitrosylation.GSNOR通过蛋白质S-亚硝基化调节心肌细胞的分化和成熟。
J Cardiovasc Aging. 2021;1. doi: 10.20517/jca.2021.25. Epub 2021 Oct 13.
10
Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage.氧化和亚硝化翻译后修饰在抗再灌注损伤治疗策略中的意义
Antioxidants (Basel). 2021 May 8;10(5):749. doi: 10.3390/antiox10050749.
本文引用的文献
1
S-nitrosylation in cardiovascular signaling.心血管信号转导中的 S-亚硝基化。
Circ Res. 2010 Mar 5;106(4):633-46. doi: 10.1161/CIRCRESAHA.109.207381.
2
Protein denitrosylation: enzymatic mechanisms and cellular functions.蛋白质去亚硝基化：酶促机制与细胞功能
Nat Rev Mol Cell Biol. 2009 Oct;10(10):721-32. doi: 10.1038/nrm2764. Epub 2009 Sep 9.
3
Protein S-nitrosylation in health and disease: a current perspective.健康与疾病中的蛋白质S-亚硝基化：当前观点
Trends Mol Med. 2009 Sep;15(9):391-404. doi: 10.1016/j.molmed.2009.06.007. Epub 2009 Aug 31.
4
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.福音蛋白：一种在S-亚硝基化时与甘油醛-3-磷酸脱氢酶结合的神经保护蛋白。
Neuron. 2009 Jul 16;63(1):81-91. doi: 10.1016/j.neuron.2009.05.024.
5
Estrogen receptor-beta activation results in S-nitrosylation of proteins involved in cardioprotection.雌激素受体-β激活导致参与心脏保护的蛋白质发生S-亚硝基化。
Circulation. 2009 Jul 21;120(3):245-54. doi: 10.1161/CIRCULATIONAHA.109.868729. Epub 2009 Jul 6.
6
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.一种线粒体靶向的S-亚硝基硫醇可调节呼吸作用、使硫醇亚硝化，并预防缺血再灌注损伤。
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15.
7
Redox signaling and protein phosphorylation in mitochondria: progress and prospects.线粒体中的氧化还原信号传导与蛋白质磷酸化：进展与展望
J Bioenerg Biomembr. 2009 Apr;41(2):159-68. doi: 10.1007/s10863-009-9217-7.
8
Absence of nitric-oxide synthase in sequentially purified rat liver mitochondria.在顺序纯化的大鼠肝脏线粒体中一氧化氮合酶的缺失。
J Biol Chem. 2009 Jul 24;284(30):19843-55. doi: 10.1074/jbc.M109.003301. Epub 2009 Apr 16.
9
Erythropoietin protects the heart from ventricular arrhythmia during ischemia and reperfusion via neuronal nitric-oxide synthase.促红细胞生成素通过神经元型一氧化氮合酶在缺血和再灌注期间保护心脏免受室性心律失常的影响。
J Pharmacol Exp Ther. 2009 Jun;329(3):900-7. doi: 10.1124/jpet.109.150896. Epub 2009 Mar 23.
10
Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart.三维电子显微镜揭示了心脏中钙离子信号传导膜系统的新细节。
J Cell Sci. 2009 Apr 1;122(Pt 7):1005-13. doi: 10.1242/jcs.028175.
Zotero 插件