Translational Medicine Branch, NHLBI, NIH, 10 Center Dr, Room 7N112, Bethesda, MD 20892, USA.
Circ Res. 2010 Feb 5;106(2):285-96. doi: 10.1161/CIRCRESAHA.109.209452.
Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group. There are emerging data suggesting that S-nitrosylation of proteins plays an important role in cardioprotection. Protein S-nitrosylation not only leads to changes in protein structure and function but also prevents these thiol(s) from further irreversible oxidative/nitrosative modification. A better understanding of the mechanism regulating protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportunities and targets for interventions in cardiovascular diseases.
一氧化氮（NO）在心血管功能调节中发挥着重要作用。除了经典的依赖 cGMP 的途径激活 NO 外，NO 还可以通过蛋白质 S-亚硝基化来调节细胞功能，这是一种依赖氧化还原、基于巯基、可逆的翻译后蛋白质修饰，涉及将 NO 部分附着到亲核蛋白质巯基基团上。有新出现的数据表明，蛋白质 S-亚硝基化在心脏保护中起着重要作用。蛋白质 S-亚硝基化不仅导致蛋白质结构和功能的变化，而且还防止这些巯基进一步发生不可逆的氧化/亚硝化修饰。更好地了解调节蛋白质 S-亚硝基化的机制及其在心脏保护中的作用，将为我们提供新的治疗机会和干预心血管疾病的靶点。
