Sun Junhui, Steenbergen Charles, Murphy Elizabeth
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1693-705. doi: 10.1089/ars.2006.8.1693.
Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. S-nitrosylation, the covalent attachment of an NO moiety to sulfhydryl residues of proteins, resulting in the formation of S-nitrosothiols (SNOs), is a prevalent posttranslational protein modification involved in redox-based cellular signaling. Under physiologic conditions, protein S-nitrosylation and SNOs provide protection preventing further cellular oxidative and nitrosative stress. However, oxidative stress and the resultant dysfunction of NO signaling have been implicated in the pathogenesis of cardiovascular diseases.
一氧化氮（NO）在心血管功能调节中发挥着重要作用。S-亚硝基化是指NO部分与蛋白质的巯基残基共价结合，导致形成S-亚硝基硫醇（SNOs），它是一种普遍存在的翻译后蛋白质修饰，参与基于氧化还原的细胞信号传导。在生理条件下，蛋白质S-亚硝基化和SNOs提供保护，防止细胞进一步受到氧化和亚硝化应激。然而，氧化应激以及由此导致的NO信号传导功能障碍与心血管疾病的发病机制有关。
