Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Japan.
Circ J. 2010 Mar;74(3):578-88. doi: 10.1253/circj.cj-09-0692. Epub 2010 Feb 4.
Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers.
The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC.
GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.
由于绿茶能降低心脑血管疾病风险，本研究旨在阐明绿茶儿茶素（GTC）对吸烟者内皮功能障碍的影响。
30 名健康男性吸烟者被分为 3 组，每天分别给予含有 0 mg（对照组）、80 mg（中剂量组）或 580 mg（高剂量组）GTC 的绿茶饮料，持续 2 周。通过使用静脉闭塞应变计容积描记法测量前臂血流（FBF）对乙酰胆碱和硝普钠的反应来研究内皮依赖性和非依赖性血管舒张。高剂量组在 GTC 摄入后 2 小时和 1 周及 2 周时，乙酰胆碱引起的 FBF 反应显著增加，但其他组没有观察到增加。任何时间点各组对硝普钠的 FBF 反应均未改变。长期摄入高剂量 GTC 后，血浆一氧化氮水平显著升高，不对称二甲基精氨酸、丙二醛和 4-羟基壬烯醛、C 反应蛋白、单核细胞趋化蛋白-1 和可溶性 CD40 配体水平降低。
GTC 通过增加一氧化氮水平和降低氧化应激，对吸烟者功能失调的血管具有抗动脉粥样硬化作用。
