Department of Medicine III, Carl Gustav Carus University Hospital, Dresden, Germany.
Neuroimmunomodulation. 2010;17(3):180-3. doi: 10.1159/000258718. Epub 2010 Feb 4.
Adrenal gland insufficiency - the clinical manifestation of deficient production or action of adrenal steroids - is a life-threatening disorder. Among many factors which can predispose to primary adrenal failure, an autoimmune adrenalitis and infectious agents play a major role. The initial host defense against bacterial infections is executed primarily by the pattern recognition receptors, e.g. Toll-like receptors (TLRs), expressed in cells from the innate immune system. Upon activation, TLRs have been found to regulate various levels of innate and adaptive immunity as well as control tissue inflammation. TLRs are implicated in adrenal cell turnover and steroidogenesis during inflammation. Therefore, TLRs play a crucial role in the activation of adrenal inflammation mediating adrenal gland dysfunction during septicemia.
肾上腺功能不全-肾上腺类固醇产生或作用不足的临床表现-是一种危及生命的疾病。在许多可能导致原发性肾上腺衰竭的因素中，自身免疫性肾上腺炎和感染因子起着重要作用。机体对细菌感染的初始宿主防御主要由先天免疫系统细胞中表达的模式识别受体（例如 Toll 样受体（TLR））执行。研究发现，TLR 激活后可调节先天免疫和适应性免疫的各个水平，并控制组织炎症。TLR 参与炎症过程中的肾上腺细胞更新和类固醇生成。因此，TLR 在败血症期间介导肾上腺炎症激活和肾上腺功能障碍中发挥关键作用。
