• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Muscling in: Uncovering the origins of rhabdomyosarcoma.

作者信息

Hettmer Simone, Wagers Amy J

机构信息

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University and Joslin Diabetes Center, Cambridge, Massachusetts, USA.

出版信息

Nat Med. 2010 Feb;16(2):171-3. doi: 10.1038/nm0210-171.

DOI:10.1038/nm0210-171
PMID:20134473
Abstract
摘要

相似文献

1
Muscling in: Uncovering the origins of rhabdomyosarcoma.强势介入：揭开横纹肌肉瘤的起源
Nat Med. 2010 Feb;16(2):171-3. doi: 10.1038/nm0210-171.
2
Muscling in on rhabdomyosarcoma.侵入横纹肌肉瘤
Nat Med. 2002 Nov;8(11):1200-1. doi: 10.1038/nm1102-1200.
3
Letter: Viral-coded information in human rhabdomyosarcoma cells.信件：人横纹肌肉瘤细胞中的病毒编码信息。
Lancet. 1974 Nov 30;2(7892):1330-1. doi: 10.1016/s0140-6736(74)90202-5.
4
Pathogenesis of a rhabdomyosarcoma (undifferentiated type) in rats induced by a murine sarcoma virus (Moloney).由鼠肉瘤病毒（莫洛尼）诱导的大鼠横纹肌肉瘤（未分化型）的发病机制。
Cancer Res. 1968 Jun;28(6):1197-206.
5
Rhabdomyosarcoma of the adult urinary bladder after radiotherapy for carcinoma.放射治疗癌后成人膀胱横纹肌肉瘤
Clin Oncol (R Coll Radiol). 1989 Nov;1(2):115-6. doi: 10.1016/s0936-6555(89)80047-0.
6
Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma.深度测序揭示了一种在横纹肌肉瘤中具有治疗潜力的新型miR-22调控网络。
Cancer Res. 2016 Oct 15;76(20):6095-6106. doi: 10.1158/0008-5472.CAN-16-0709. Epub 2016 Aug 28.
7
[Development of a rhabdomyosarcoma at the site of a pemphigus process].[天疱疮病程部位发生横纹肌肉瘤]
Vestn Dermatol Venerol. 1986(1):40-2.
8
PAX3-FOXO1 fusion gene in rhabdomyosarcoma.横纹肌肉瘤中的PAX3-FOXO1融合基因
Cancer Lett. 2008 Oct 18;270(1):10-8. doi: 10.1016/j.canlet.2008.03.035. Epub 2008 May 23.
9
Myocardial rhabdomyosarcoma in multiple neurofibromatosis.多发性神经纤维瘤病中的心肌横纹肌肉瘤
Neurology. 1981 Dec;31(12):1549-51. doi: 10.1212/wnl.31.12.1549.
10
[Rhabdomyosarcoma of the knee developing 22 years after a gunshot wound].[膝关节横纹肌肉瘤在枪伤22年后发生]
Vopr Onkol. 1967;13(8):118-9.

引用本文的文献

1
Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review).人类恶性肿瘤中的癌症相关成纤维细胞，尤其侧重于肉瘤（综述）
Int J Oncol. 2025 Oct;67(4). doi: 10.3892/ijo.2025.5785. Epub 2025 Aug 8.
2
Integrative bioinformatics analysis and experimental validation identify CHEK1 as an unfavorable prognostic biomarker related to immunosuppressive phenotypes in soft tissue sarcomas.整合生物信息学分析与实验验证确定CHEK1是与软组织肉瘤免疫抑制表型相关的不良预后生物标志物。
NPJ Precis Oncol. 2025 Aug 1;9(1):268. doi: 10.1038/s41698-025-01064-8.
3
Integrative Multi-Omics Profiling of Rhabdomyosarcoma Subtypes Reveals Distinct Molecular Pathways and Biomarker Signatures.

本文引用的文献

1
Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?肺泡横纹肌肉瘤：起源细胞是间充质干细胞吗？
Cancer Lett. 2009 Jul 8;279(2):126-36. doi: 10.1016/j.canlet.2008.09.039. Epub 2008 Nov 12.
2
Rhabdomyosarcoma masquerading as acute leukemia.伪装成急性白血病的横纹肌肉瘤。
Pediatr Blood Cancer. 2009 Feb;52(2):286-7. doi: 10.1002/pbc.21783.
3
Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations.表达PAX-FKHR的小鼠间充质干细胞通过与二次突变协同作用形成肺泡横纹肌肉瘤。
横纹肌肉瘤亚型的综合多组学分析揭示了不同的分子途径和生物标志物特征。
Cells. 2025 Jul 20;14(14):1115. doi: 10.3390/cells14141115.
4
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo.横纹肌肉瘤融合癌蛋白最初在体内开创了一种神经特征。
Cell Rep. 2025 Jul 22;44(7):115923. doi: 10.1016/j.celrep.2025.115923. Epub 2025 Jul 3.
5
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors.患者来源的横纹肌肉瘤细胞概括了原发性肿瘤的基因和转录组图谱。
iScience. 2024 Aug 31;27(10):110862. doi: 10.1016/j.isci.2024.110862. eCollection 2024 Oct 18.
6
Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma.单细胞转录组谱分析鉴定小儿横纹肌肉瘤中的肿瘤获得性和治疗耐药细胞状态。
Nat Commun. 2024 Jul 26;15(1):6307. doi: 10.1038/s41467-024-50527-2.
7
Evaluation of the Role of AXL in Fusion-positive Pediatric Rhabdomyosarcoma Identifies the Small-molecule Inhibitor Bemcentinib (BGB324) as Potent Chemosensitizer.评价 AXL 在融合阳性小儿横纹肌肉瘤中的作用，发现小分子抑制剂贝美替尼（BGB324）作为有效的化疗增敏剂。
Mol Cancer Ther. 2024 Jun 4;23(6):864-876. doi: 10.1158/1535-7163.MCT-23-0285.
8
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning.骨骼肌分泌的二脂酰甘油调控系统能量平衡，促进脂肪褐变。
Nat Commun. 2023 Nov 30;14(1):7916. doi: 10.1038/s41467-023-43402-z.
9
PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors.PAX3-FOXO1 决定内皮祖细胞的成肌重编程和横纹肌肉瘤特性。
Nat Commun. 2023 Nov 15;14(1):7291. doi: 10.1038/s41467-023-43044-1.
10
Staufen1 controls mitochondrial metabolism via HIF2α in embryonal rhabdomyosarcoma and promotes tumorigenesis.Staufen1 通过 HIF2α 控制胚胎横纹肌肉瘤中的线粒体代谢，并促进肿瘤发生。
Cell Mol Life Sci. 2023 Oct 17;80(11):328. doi: 10.1007/s00018-023-04969-4.
Cancer Res. 2008 Aug 15;68(16):6587-97. doi: 10.1158/0008-5472.CAN-08-0859.
4
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.髓母细胞瘤可由谱系受限的祖细胞或干细胞中patched基因的缺失引发。
Cancer Cell. 2008 Aug 12;14(2):135-45. doi: 10.1016/j.ccr.2008.07.003.
5
Genetic diagnosis of alveolar rhabdomyosarcoma in the bone marrow of a patient without evidence of primary tumor.在一名无原发性肿瘤证据患者的骨髓中对肺泡横纹肌肉瘤进行基因诊断。
Pediatr Blood Cancer. 2008 Oct;51(4):554-7. doi: 10.1002/pbc.21646.
6
Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups.转移性横纹肌肉瘤的预后因素：来自美国和欧洲合作组的汇总分析结果
J Clin Oncol. 2008 May 10;26(14):2384-9. doi: 10.1200/JCO.2007.14.7207.
7
The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.横纹肌肉瘤的PAX3-FKHR融合基因与p16INK4A缺失协同作用，促进细胞衰老的旁路激活。
Cancer Res. 2007 Jul 15;67(14):6691-9. doi: 10.1158/0008-5472.CAN-06-3210.
8
Effects of RAS on the genesis of embryonal rhabdomyosarcoma.肾素-血管紧张素系统（RAS）对胚胎性横纹肌肉瘤发生的影响。
Genes Dev. 2007 Jun 1;21(11):1382-95. doi: 10.1101/gad.1545007. Epub 2007 May 17.
9
Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis.肌肉再生的细胞和分子特征：成体肌生成中的当前概念与争议
Cell. 2005 Sep 9;122(5):659-67. doi: 10.1016/j.cell.2005.08.021.
10
New genetic tactics to model alveolar rhabdomyosarcoma in the mouse.在小鼠中模拟肺泡横纹肌肉瘤的新基因策略。
Cancer Res. 2005 Sep 1;65(17):7530-2. doi: 10.1158/0008-5472.CAN-05-0477.