Lamoureux G, Duquette P, Lapierre Y, Cosgrove B, Bourret G, Labrie L
J Neurol. 1983;230(2):91-104. doi: 10.1007/BF00313636.
Patients with multiple sclerosis (MS) from the two Montreal MS clinics, were divided into two groups: one group of 61 patients (MS type I) who had no clinical history of susceptibility to recurrent respiratory tract infections and a second group of 58 patients (MS type II) who had persistent susceptibility to such infections since childhood. All patients were typed for the HLA tissue antigens. The HLA antigen frequencies of the total MS patient population, and of MS type I and MS type II patients were compared to those of a normal control population and each other. The HLA-DR2 and B7 antigen frequencies were significantly increased compared to the normal controls for all MS patients. MS type I patients had an increased frequency for HLA-Bw42 and DRw8 antigens; the frequency of HLA-A29 was lower than in the controls and MS type II patients. MS type II patients had a significantly increased frequency for DR3 and some HLA-DR3-associated phenotypes (A1 + DR3; B8 + DR3; A1 + B8 + DR3) as compared to controls and MS type I patients. These results are consistent with the existence of genes linked to the HLA antigens, such as immune response genes, which control the resistance or susceptibility of the patients to infection, and suggest that these HLA antigens could be associated with a difference in the evolution of MS, as observed in the MS type I and II patients [21].
来自蒙特利尔两家多发性硬化症（MS）诊所的患者被分为两组：一组61名患者（I型MS），他们没有反复呼吸道感染易感性的临床病史；另一组58名患者（II型MS），他们自童年起就持续易患此类感染。所有患者均进行了HLA组织抗原分型。将整个MS患者群体以及I型和II型MS患者的HLA抗原频率与正常对照群体的频率进行比较，并相互比较。与正常对照相比，所有MS患者的HLA-DR2和B7抗原频率显著增加。I型MS患者的HLA-Bw42和DRw8抗原频率增加；HLA-A29的频率低于对照组和II型MS患者。与对照组和I型MS患者相比，II型MS患者的DR3以及一些与HLA-DR3相关的表型（A1 + DR3；B8 + DR3；A1 + B8 + DR3）频率显著增加。这些结果与存在与HLA抗原相关的基因（如免疫反应基因）一致，这些基因控制患者对感染的抵抗力或易感性，并表明这些HLA抗原可能与MS演变的差异有关，如在I型和II型MS患者中观察到的那样[21]。
